Figure 2

Histology (a, b) and immunohistochemistry (c-f) of sclerosing hemangioma of the lung: a) Well-circumscribed lesion with normal lung tissue in the right upper corner (X), lymphoid cell infiltration (arrows) and hemorrhages (dashed arrow); hematoxylin and eosin stain (25x) b) Mixed growth pattern of the lesion, papillary (arrows), solid (dashed arrows) and sclerotic (*); foam cells (dotted arrows); hematoxylin and eosin stain (200x) c) Cuboidal surface cells positive for staining with pan-cytokeratin antibody (200x) d) Epithelial membrane antigen (EMA) and e) thyroid transcription factor 1 (TTF-1) are positive in both cuboidal surface cells as well as stromal round cells (200x) f) Positive nuclear staining for Ki67 in only few cells (Ki-67-Index < 5%) (200x).