Figure 6

Effects of combined treatment with AS clusterin ODN plus gmcitabine on BxPC-3 tumor growth. Mice bearing BxPC-3 tumor were randomly selected for treatment with AS clusterin ODN, MM control ODN, AS clusterin ODN plus gmcitabine, or MM control ODN plus gmcitabine. After tumor cell injection (7 days), 10 mg/kg AS clusterin ODN or MM control ODN was daily injected i.p. for 28 days. gmcitabine (40 μM) was injected i.v. twice a week for 2 weeks. Tumor volume was measured once weekly and calculated by the formula: length × width × depth × 0.5. Each point represents the mean tumor volume in each experimental group containing eight mice with SD. *, differs from controls (*P < 0.01) by Student's t test.