Table 2 Showing the Isoforms of MT on Tumorgenesis
From: A Review of Metallothionein Isoforms and their Role in Pathophysiology
S.NO | CANCER | ISOFORMS | ROLE |
|---|---|---|---|
1 | Breast Cancer | MT-1 A,E,F,X, H,G, MT-3, MT-2A. | 1) MT-1E: Alternative processes that replace the function of estrogen i;e breast cancer tumorgenesis. 2) MT-3: Poor prognosis for patients with breast cancer. |
| Â | Â | Â | 3) MT-2A: Detected in breast tissue is positively correlated with cell proliferation and histological grade. 4) MT-1F: It found to influence histological differentiation in invasive breast cancer. |
2 | Renal Cancer | MT-1A, MT-1G, MT-IX, MT-3. | 1) MT-3: Normal kidney & also in renal cell carcinoma, cancerous bladder tissues,(which was absent in normal bladder tissues)prostatic adenocarcinoma.. 2) MT-IX:Bladder cancer. |
3 | Prostate Cancer | MT-1A, MT-1E, MT-1X, MT-2A, MT-1, MT-2. | 1) MT-IX:Advanced prostate cancer. 2) MT-1, MT-2: proliferative activity of breast, colon & prostate human cancer. |
4 | Papillary Thyroid Cancer | MT-1, MT-2. | Thyroid Cancer cells (KAT5 cells) + Calcium elevated ERK1/2 → 8 functional MT-1&MT2 induced By cd → MT expression+ Decrease in G0, G1 phase, Increase in G2-M phase → Novel pathway for Functional MT expression. |