Table 1 Classification of MT-Isomers
From: A Review of Metallothionein Isoforms and their Role in Pathophysiology
S.No | Based on | Classification | |
|---|---|---|---|
1. | Metals Present | Major -MT-1 &MT-2 | |
| Â | Â | Minor - MT-3 &MT-4 | |
2. | Proteins are encoded by a family of genes which are located on chromosome 16q13 | MT I a, MT I b, MT I c etc | |
3. | Biological system | Central nervous system | MT-I, MT-II and MT-III |
| Â | Â | Neurons | MT-III |
4. | Family of eukaryote and some are in prokaryote | Proteins with sequences related to mammalian MT | MT- i |
| Â | Â | Proteins with sequences not related to mammalian MT | MT- ii |
| Â | Â | Peptides that are not genetically encoded | MT- iii |
5. | Expressed in tissues | Liver and kidney | MT-I and MT-II |
| Â | Â | Brain and to male reproductive organs | MT-III |
| Â | Â | Specific to stratified squamous epithelia | MT-IV |