Figure 5
Microscopic appearance of the lesion. (A) Low-power view of the tumor showing dense lymphocytic infiltration with lymph follicles (hematoxylin and eosin, original magnification ×4). (B) Interfollicular areas are infiltrated with small to intermediate-sized lymphocytes with pale cytoplasm, which are characteristic features of hepatic pseudolymphoma as well as marginal zone B-cell lymphoma (hematoxylin and eosin, original magnification ×40). (C) Intermediate-sized atypical lymphocytes are observed (hematoxylin and eosin, original magnification ×40). (D) Most of the lymphoid cells are positive for CD20. These cells are negative for CD5, which rules out other small B-cell non Hodgkin lymphomas, including lymphocytic lymphoma and mantle cell lymphoma (original magnification ×4). (E) Bcl-2 expression in the mantle zones and the interfollicular areas (original magnification ×4). (F) Lymphoepithelial lesions are observed at the bile ducts (hematoxylin and eosin, original magnification ×40). (G) At the edge of the nodule, lymphocytic infiltration extends into perinodular portal tracts (hematoxylin and eosin, original magnification ×10). (H) Bile ducts are observed at the periphery of the nodule (hematoxylin and eosin, original magnification ×10).