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Table 3 Univariate and multivariate analyses of clinicopathological factors affecting CRC recurrence in all patients after liver resection for hepatic metastases.

From: Outcomes of resection for colorectal cancer hepatic metastases stratified by evolving eras of treatment

Factors

Univariate analysis

Multivariate analysis

 

n

Medium RFS months (95% CI)

p value

p value (HR, 95% CI)

Age (years)

    

   < 65

173

10.0 (8.4-11.6)

0.103

-

   ≥65

106

16.9 (9.9-24.0)

  

Gender

    

   Male

177

12.0 (7.7-16.3)

0.021

0.134

   Female

102

11.0 (9.0-13.0)

  

Primary tumor

    

   Colon

156

12.9 (8.5-17.2)

0.234

-

   Rectum

123

10.0 (8.5-11.5)

  

Serum CEA (mg/dL)

    

   < 200

198

12.0 (10.6-13.4)

0.567

-

   ≥200

72

10.0 (7.3-12.7)

  

Metastatic type

    

   Synchronous

179

10.8 (9.3-12.3)

0.002

0.014

   Metachronous

100

15.0 (9.1-20.9)

 

1.5 (1.1-2.0)

Tumor number

    

   Solitary

181

14.0 (8.9-19.1)

0.001

0.028

   Multiple

98

10.0 (7.8-8.7)

 

1.4 (1.0-1.9)

Maximum tumor size

    

   < 5 cm

230

12.0 (10.0-14.0)

0.420

-

   ≥5 cm

49

10.0 (6.9-13.1)

  

Extent of liver resection

    

   < 3 segments

202

12.0 (9.3-14.7)

0.235

-

   ≥3 segments

77

10.0 (7.9-12.1)

  

Resection margin (cm)

    

   < 0.5

147

10.0 (8.5-11.5)

0.019

0.073

   ≥0.5

132

14.5 (9.1-19.9)

  

Histologic grade

    

   Low grade

261

12.0 (9.3-14.7)

0.184

-

   high grade

18

5.3 (1.8-8.8)

  
  1. RFS, recurrence free survival; CRC, colorectal cancer; CEA, carcinoembryonic antigen; CI, confidence interval; HR, hazard ratio