Skip to main content

Table 2 Univariate and multivariate analyses of clinicopathological factors affecting CRC recurrence of patients after liver resection for hepatic metastases in different eras.

From: Outcomes of resection for colorectal cancer hepatic metastases stratified by evolving eras of treatment

Factors

Era 1

Era 2

 

Univariate

Multivariate

Univariate

Multivariate

 

n

Medium RFS months (95%CI)

p value

p value

n

Medium RFS months (95%CI)

p value

p value

Age (years)

        

   < 65

89

8.0 (6.9-9.0)

0.296

-

84

12.0 (8.3-15.7)

0.300

-

   ≥65

39

12.0 (9.7-14.3)

  

67

21.0 (16.4-25.7)

  

Gender

        

   Female

52

10.0 (8.1-11.9)

0.274

-

50

24.4 (11.7-37.1)

0.014

0.218

   Male

76

9.0 (7.5-10.4)

  

101

14.5 (10.1-18.9)

  

Primary tumor

        

   Colon

65

11.0 (8.9-13.0)

0.116

-

91

17.5 (10.4-24.6)

0.961

-

   Rectum

63

8.0 (6.1-9.9)

  

60

16 (6.6-25.3)

  

Serum CEA (mg/dL)

        

   ≤200

83

11.0 (8.8-13.1)

0.550

-

115

17.5 (11.0-24.0)

0.362

-

   > 200

38

9.0 (7.8-10.1)

  

94

15.3 (6.5-24.0)

  

Metastatic type

        

   Synchronous

85

8.0 (6.8-9.2)

0.052

0.075

94

12.9 (8.5-17.3)

0.009

0.076

   Metachronous

43

11.0 (8.8-13.1)

  

57

21.0 (7.4-34.7)

  

Tumor number

        

   Solitary

97

10.0 (8.8-11.1)

0.022

0.035

84

22.1 (16.5-27.8)

0.001

0.028

   Multiple

31

7.0 (5.3-8.7)

 

1.6 (1.0-2.5)

67

12.0 (10.6-13.5)

 

1.6 (1.1-2.4)

Maximum tumor size

        

   < 5 cm

108

10.0 (8.8-11.2)

0.939

-

122

18.0 (12.6-23.5)

0.162

-

   ≥5 cm

20

8.0 (3.1-2.9)

  

29

11.9 (6.9-16.8)

  

Liver resection extent

        

   < 3 segments

88

10.0 (8.5-11.4)

0.743

-

114

17.5 (11.1-23.9)

0.257

-

   ≥3 segments

40

9.0 (7.6-10.4)

  

37

13.0 (6.0-19.9)

  

Resection margin (cm)

        

   < 0.5

60

9.0 (7.5-10.4)

0.773

-

87

12.0 (10.3-13.7)

0.001

0.011

   ≥0.5

68

10.0 (8.0-11.9)

  

64

23.3 (16.9-29.6)

 

1.7 (1.1-2.6)

Histology grade

        

   Low grade

116

10.0 (8.8-11.2)

0.101

-

145

16.5 (11.0-22.0)

0.921

-

   High grade

12

5.0 (2.1-7.9)

  

6

5.3 (0.0-30.4)

  
  1. RFS, recurrence-free survival; CRC, colorectal cancer; CEA, carcinoembryonic antigen; CI, confidence interval