Factors | Era 1 | Era 2 | ||||||
---|---|---|---|---|---|---|---|---|
 | Univariate | Multivariate | Univariate | Multivariate | ||||
 | n | Medium RFS months (95%CI) | p value | p value | n | Medium RFS months (95%CI) | p value | p value |
Age (years) | Â | Â | Â | Â | Â | Â | Â | Â |
   < 65 | 89 | 8.0 (6.9-9.0) | 0.296 | - | 84 | 12.0 (8.3-15.7) | 0.300 | - |
   ≥65 | 39 | 12.0 (9.7-14.3) |  |  | 67 | 21.0 (16.4-25.7) |  |  |
Gender | Â | Â | Â | Â | Â | Â | Â | Â |
   Female | 52 | 10.0 (8.1-11.9) | 0.274 | - | 50 | 24.4 (11.7-37.1) | 0.014 | 0.218 |
   Male | 76 | 9.0 (7.5-10.4) |  |  | 101 | 14.5 (10.1-18.9) |  |  |
Primary tumor | Â | Â | Â | Â | Â | Â | Â | Â |
   Colon | 65 | 11.0 (8.9-13.0) | 0.116 | - | 91 | 17.5 (10.4-24.6) | 0.961 | - |
   Rectum | 63 | 8.0 (6.1-9.9) |  |  | 60 | 16 (6.6-25.3) |  |  |
Serum CEA (mg/dL) | Â | Â | Â | Â | Â | Â | Â | Â |
   ≤200 | 83 | 11.0 (8.8-13.1) | 0.550 | - | 115 | 17.5 (11.0-24.0) | 0.362 | - |
   > 200 | 38 | 9.0 (7.8-10.1) |  |  | 94 | 15.3 (6.5-24.0) |  |  |
Metastatic type | Â | Â | Â | Â | Â | Â | Â | Â |
   Synchronous | 85 | 8.0 (6.8-9.2) | 0.052 | 0.075 | 94 | 12.9 (8.5-17.3) | 0.009 | 0.076 |
   Metachronous | 43 | 11.0 (8.8-13.1) |  |  | 57 | 21.0 (7.4-34.7) |  |  |
Tumor number | Â | Â | Â | Â | Â | Â | Â | Â |
   Solitary | 97 | 10.0 (8.8-11.1) | 0.022 | 0.035 | 84 | 22.1 (16.5-27.8) | 0.001 | 0.028 |
   Multiple | 31 | 7.0 (5.3-8.7) |  | 1.6 (1.0-2.5) | 67 | 12.0 (10.6-13.5) |  | 1.6 (1.1-2.4) |
Maximum tumor size | Â | Â | Â | Â | Â | Â | Â | Â |
   < 5 cm | 108 | 10.0 (8.8-11.2) | 0.939 | - | 122 | 18.0 (12.6-23.5) | 0.162 | - |
   ≥5 cm | 20 | 8.0 (3.1-2.9) |  |  | 29 | 11.9 (6.9-16.8) |  |  |
Liver resection extent | Â | Â | Â | Â | Â | Â | Â | Â |
   < 3 segments | 88 | 10.0 (8.5-11.4) | 0.743 | - | 114 | 17.5 (11.1-23.9) | 0.257 | - |
   ≥3 segments | 40 | 9.0 (7.6-10.4) |  |  | 37 | 13.0 (6.0-19.9) |  |  |
Resection margin (cm) | Â | Â | Â | Â | Â | Â | Â | Â |
   < 0.5 | 60 | 9.0 (7.5-10.4) | 0.773 | - | 87 | 12.0 (10.3-13.7) | 0.001 | 0.011 |
   ≥0.5 | 68 | 10.0 (8.0-11.9) |  |  | 64 | 23.3 (16.9-29.6) |  | 1.7 (1.1-2.6) |
Histology grade | Â | Â | Â | Â | Â | Â | Â | Â |
   Low grade | 116 | 10.0 (8.8-11.2) | 0.101 | - | 145 | 16.5 (11.0-22.0) | 0.921 | - |
   High grade | 12 | 5.0 (2.1-7.9) |  |  | 6 | 5.3 (0.0-30.4) |  |  |