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Table 3 Chemotherapy compliance after lobectomy by different approach

From: Video-assisted thoracoscopic surgery is more favorable than thoracotomy for administration of adjuvant chemotherapy after lobectomy for non-small cell lung cancer

  VATS
n = 54
Thoracotomy
n = 56
p value
Chemotherapy regimens, no. (%)    0.577
   Gemcitabine+Cisplatin 25 (46.3) 29 (51.8)  
   Paclitaxol+Carboplatin 22(40.7) 23(41.1)  
   Vinorelbine+Cisplatin 7(13.0) 4(7.1)  
Time to initiate chemotherapy(days) 33.7 ± 10.9 34.0 ± 13.3 0.904
Cycles completed, (Mean ± SD) 3.6 ± 0.72 3.0 ± 1.1 0.002*
Pts. Receive full dose on schedule, no. (%) 31 (57.4) 19 (33.9) 0.013
Pts. Receive ≥75% planed dose, no. (%) 48(88.9) 40(71.4) 0.022*
Mean doses, (% of planed)    
   Cisplatin (mg/m2) 267 (89.0) 237 (79.0) 0.121
   Gemcitabine (mg/m2) 8900 (9.0) 7930 (79.3) 0.120
   Paclitaxol (mg/m2) 620 (88.6) 495 (70.7) 0.020*
   Carboplatin (AUC mg/ml/min) 21.3 (88.8) 17.0 (70.8) 0.019*
Toxicity, no. (%)    0.011*
   Grade 1/2 toxicity 25 (46.3) 34 (60.7) 0.130
   Grade 3/4 toxicity 11 (20.4) 20 (35.7) 0.074