Table 6 Uni- and multivariate analysis of factors for overall survival after recurrence

Primary Tumor

Tumor size

2.0 cm </≤2.0 cm

primary tumor

0.98

0.93

Nodal status

0/1-3/4+

primary tumor

1.39

0.15

Nuclear Grade

1/2/3

primary tumor

1.55

0.22

Ki-67

50%≤/< 50%

primary tumor

5.67

0.0002

0.0006

ER

+/-

primary tumor

0.49

0.07

0.09

PgR

+/-

primary tumor

0.43

0.037

0.35

p53

+/-

primary tumor

2.18

0.058

0.11

HER2

+/-

primary tumor

0.9

0.82

Recurrent Tumor

DFI

5y≤/2y≤/< 2y

at recurrence

0.73

0.22

Ki-67

50%≤/< 50%

recurrent tumor

2.88

0.009

0.32

ER

+/-

recurrent tumor

0.36

0.013

0.51

PgR

+/-

recurrent tumor

0.25

0.005

0.046

p53

+/-

recurrent tumor

1.78

0.16

HER2

+/-

recurrent tumor

0.95

0.91

Distant metastasis

+/-

at recurrence

2.56

0.017

0.043