Table 1 Studies assessing the risk of oesophageal cancer in relation to oestrogen receptors.
From: Probing the link between oestrogen receptors and oesophageal cancer
|  | No of patients | M:F | PR | ER-α | ER-β | Histological subtypes of OC | Source & affinity of ER AB | Significance/Dedifferentiation |
|---|---|---|---|---|---|---|---|---|
Kalayarasan et al., (India, 2008)[39] | 45 | 3:2 (SCC) 4:1(AC) | 0 | 0 | 45 | AC (n = 15) SCC (n = 30) AC>SCC | Novacastra- ERα- Clone 6F11- ERβ- Clone EMR02- | ERβ staining increases with dedifferentiation |
Boone J et al, (Netherlands,2009)[54] | 108 (Tissue Microarray) |  | 0 | 0 |  | 100% s SCC | Dako- M7047 | No staining found with ERα |
Nozoe T et al.,(Japan, 2007)[46] | 73 | 10:1 | ND | 47 | 21 | 100% SCC | Santa Cruz- HC-20(α) H-150(β) | ERα expression -unfavourable independent prognostic indicator |
Tiffin et al., (UK,2003)[40] | 20 | 1:1 | ND | ND | ND | ER= +ve (n = 8 AC) | Dako- NS | Oestrogen receptors are more important than androgen receptors-require further investigations |
Wang L et al., (China,1991)[56] | 48 | Â | 19 | Unknown | Unknown | Unknown | Unknown | Gender & grade of tumour were influencing ER expression |
Akgun et al., (USA,2002)[49] | 31 | ND | ND | NA | 23 | AC | NS- MYEB(β) | AC, BM show higher expression of ERβ |
Liu et al., (USA, 2004)[55] | 33 | ND | ND | NA | ERβ 1 = 23/27 ERβ 2 = 22/27 ERβ 3 = 27/27 ERβ5 = 27/27 | ACC>Barrett's metaplasia negative for dysplasia | In house- Human ER-β (amino acids 1-12). | ERβ subtypes are overexpressed in oesophgael cancer as compared to its precursor lesions |