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Table 4 Summary of outcomes reported in the included studies

From: Repeat hepatectomy for recurrent hepatocellular carcinoma: a local experience and a systematic review

Variable

No. of studies with available information

Median (range)

Intrahepatic recurrences rate after Initial Hx (%)

215, 9, 10, 12-15, 17, 21-27, 29-34

55.2 (34.6-78)

Median/mean recurrent intervals (months) after initial Hx

155, 8, 10, 13-16, 18, 22, 27, 28, 30-33

22.4 (6-33.3)

Resectability rate (%)

235, 9, 10, 12-17, 20-27, 29-34

22.8 (8.7-44)

No. of repeat Hx

295, 9-35

1149*

Mean age (years)

178, 10, 11, 13-17, 20, 22, 26, 28, 30-32, 34, 35

59.5 (45-66.9)

Male (%)

198, 10, 11, 13-19, 22, 26, 28, 30-32, 34, 35

81.2 (68-91.6)

Liver cirrhosis (%)

158-11, 14-17, 19, 20, 22, 26, 28, 30, 31

68.6 (36-100)

Solitary recurrent HCC (%)

198, 9, 13-20, 22, 24, 26, 28, 30-32,34, 35

64.2 (37.5-83.3)

Maxium tumor size <3 cm (%)

88, 9, 14, 15, 19, 26, 31, 35

63.6 (27-76.1)

Minor resection (%)

188-18, 22, 26, 30- 32, 34

95.5 (71.4-100)

Median/mean operating time (min)

913, 15, 16, 19, 22, 26, 30, 32, 34

267(136-365)

Median/mean blood loss (mL)

1313-16, 19, 22, 26, 28-30, 32, 34, 35

603 (211-1980)

Morbidity (%)

1210, 13, 15, 16, 18, 22, 28-32, 35

23.5 (6.2-68.2)

Mortality (%)

245, 8-10, 12-23, 26, 28-32, 34, 35

0 (0-8.0)

Overall survival after recurrence

  

   Median time (months)

88, 10, 14, 15, 18, 22, 28, 33

27.1 (21-61.5)

   1-year (%)

255, 8-22, 25-31,34, 35

91.0(69-100)

   3-year (%)

265, 8-24, 26-31, 34, 35

63.4 (21.0-87.0)

   5-year (%)

225, 9, 11-14, 16, 17, 19, 21, 23, 24, 26-35

48.5(25.0-87.0)

  1. Hx: hepatectomy. HCC: hepatocellular carcinoma. * total