Figure 1

Immunohistochemical detection of HMGB1 protein in different gastric tissues. A: Normal rectal sample. The low-expression of HMGB1 was detected in epithelial and stromal cells B: Gastric adenocarcinoma sample with well differentiation. The immunohistochemical staining showed strong positive signal (+ + +) in the cancer cells, and low-expression was detected in the stromal cells, which localized in the nucleus. C: Gastric adenocarcinoma sample with poor-moderate differentiation. The immunohistochemical staining showed strong positive signal (+ + +), which mainly localized in the nucleus. D: In rare cases, the strong staining was detected in the nucleus and cytoplasm of the cancer cells. Original magnification × 200.