Table 5 Most frequently detected regions in both blood and tissue group by array CGH
From: Genomic alterations of primary tumor and blood in invasive ductal carcinoma of breast
Cytoband | Bac_position(Start-End) | Gene | Blood frequency | Tissue frequency |
|---|---|---|---|---|
copy number gain | Â | Â | Â | Â |
1q23.1 | 155045002-155148010 | SH2D2A, NTRK1, INSRR | 11/30(37%) | 14/30(47%) |
3q21.1 | 124077821-124170592 | DIRC2, SEMA5B | 12/30(40%) | 12/30(40%) |
4p16.3 | 2729092-2810076 | SH3BP2 | 15/30(50%) | 10/30(33%) |
5p15.33 | 388661-566921 | AHRR, EXOC3, SLC9A3 | 17/30(57%) | 24/30(80%) |
5p15.33 | 557250-688780 | SLC9A3, CEP72 | 14/30(47%) | 24/30(80%) |
8q24.3 | 145649003-145759358 | CYHR1, KIFC2, FOXH1, PPP1R16A, GPT, MFSD3, RECQL4, LRRC14, LRRC24 | 10/30(33%) | 23/30(76%) |
8q24.3 | 145298570-145384455 | Â | 20/30(67%) | 18/30(60%) |
8q24.3 | 145499155-145579895 | HSF1, DGAT1, SCRT1, FBXL6, GPR172A, ADCK5 | 16/30(53%) | 19/30(63%) |
10q26.3 | 134654530-134754530 | GPR123 | 11/30(37%) | 12/30(40%) |
11p15.4 | 2812494-2941798 | KCNQ1, KCNQ1DN, CDKN1C, SLC22A18AS, SLC22A18, PHLDA2, NAP1L4 | 12/30(40%) | 10/30(33%) |
11p15.5 | 499204-651925 | HRAS, LRRC56, C11orf35, RASSF7, IRF7, MUCDHL, SCT, DRD4, DEAF1 | 18/30(60%) | 11/30(37%) |
11p15.5 | 982365-1053559 | AP2A2, MUC6 | 13/30(43%) | 14/30(47%) |
11p15.5-11p15.4 | 2759787-2881783 | KCNQ1, KCNQ1DN, CDKN1C, SLC22A18AS, SLC22A18 | 12/30(40%) | 13/30(43%) |
12p13.31 | 6232178-6365032 | PLEKHG6, TNFRSF1A, SCNN1A, LTBR | 18/30(60%) | 10/30(33%) |
12p13.33 | 183679-257363 | SLC6A12, SLC6A13 | 12/30(40%) | 12/30(40%) |
12q21.2 | 74611385-74763510 | PHLDA1, NAP1L1 | 10/30(33%) | 10/30(33%) |
14q32.12 | 91451809-91569634 | FBLN5, TRIP11, PTMAP7 | 13/30(43%) | 11/30(37%) |
15q12 | 24429411-24553848 | GABRB3 | 10/30(33%) | 10/30(33%) |
16p13.3 | 979471-1055445 | Â | 16/30(53%) | 23/30(76%) |
16p13.3 | 3369954-3513708 | HS3ST4, ZNF434, ZNF174, ZNF597, CLUAP1 | 12/30(40%) | 11/30(37%) |
16q22.1 | 65485602-65560334 | CDH16, RRAD, FAM96B, CES2 | 12/30(40%) | 11/30(37%) |
17p13.3 | 907028-1022423 | ABR, MRPL14P1 | 14/30(47%) | 10/30(33%) |
17q11.2 | 24429872-24521087 | MYO18A | 17/30(57%) | 19/30(63%) |
17q21.1 | 35466169-35565677 | THRA, NR1D1, CASC3 | 10/30(33%) | 11/30(37%) |
17q25.3 | 78432676-78562724 | TBCD, B3GNTL1 | 11/30(37%) | 18/30(60%) |
17q25.3 | 77755881-77849251 | SLC16A3, CSNK1D | 18/30(60%) | 17/30(57%) |
19p13.3 | 5809230-5915258 | FUT5, NDUFA11, CAPS, RANBP3 | 14/30(47%) | 13/30(43%) |
19q13.43 | 63514606-63629648 | HKR2, A1BG, ZNF497, RPS5, ZNF584 | 11/30(37%) | 10/30(33%) |
20q13.33 | 60334240-60438865 | LAMA5, RPS21, CABLES2, C20orf151 | 16/30(53%) | 19/30(63%) |
22q13.33 | 48930979-49068912 | MOV10L1, PANX2, TUBGCP6, HDAC10, MAPK12, MAPK11, PLXNB2 | 15/30(50%) | 15/30(50%) |
copy number loss | Â | Â | Â | Â |
6p25.3 | 202426-307948 | DUSP22 | 6/30(20%) | 5/30(17%) |
7q22.1 | 100407386-100480418 | MUC12, MUC17 | 6/30(20%) | 6/30(20%) |
14q32.33 | 105821330-105907464 | IGHVIII-25-1, IGHV2-26, IGHVIII-26-1, IGHVII-26-2, IGHV7-27, IGHV4-28, IGHVII-28-1, IGHV3-29, IGHV3-30, IGHVII-30-1, IGHV3-30-2, IGHV4-31, IGHVII-31-1, IGHV3-32, IGHV3-33, IGHVII-33-1, IGHV3-33-2, IGHV4-34, IGHV7-34-1 | 8/30(27%) | 8/30(27%) |
22q11.1(Cross-Hybridized) | 14461738-14573360 | DUXAP8 | 7/30(23%) | 5/30(17%) |
22q11.21 | 17158480-17233217 | GGT2 | 14/30(47%) | 11/30(37%) |