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Table 2 Cyclin E and its role in different types of cancer

From: Cell cyclins: triggering elements of cancer or not?

Breast cancer

poor disease free survival

Poor overall survival

High tumor grade

High tumor stage

Lack of steroid receptors

HER - 2/neu expression

Ki - 67 expression

BRCA1 germline mutations

Triple negative breast tumours

Basal - type keratins (CK 5/6 or CK17) expression

Bone, visceral and in general distant relapse

Ovarian Cancer

Controversial correlation with prognosis

Serous, clear cell and poorly differentiated carcinomas

Higher tumour grade

Late stage disease

Patient age more than 60 years old at the time of diagnosis

Suboptimal cytoreduction

Controversial correlation with lifetime ovulatory cycles (LOC)

No correlation with the chemotherapy response

Marker of aggressive disease in patients with metastatic ovarian carcinoma (low molecular weight isoforms)

Gastric cancer

Promotion of the progression of early gastric cancer

Prediction of the survival in early - onset gastric cancer (LMW isoforms)

Poor histological grade

Serosa invasion

Advanced stage

Tumour size (p > 0.05)

Lymphatic invasion

CDK - 2 expression

pRb expression

Colorectal carcinomas

Increased risk of recurrence

Worse outcome

Possible prognostic marker in non metastatic colon cancer

Correlation with p21 waf1/cip1 and cell proliferation

Blood vessel invasion

Gross configuration of the tumour

Independent prognostic factor in rectal carcinoma at stage I - III

Melanomas

Histological type

Tumour stage

Significant association with some specific tumour subtypes

Non small cell lung carcinoma

Poorer survival among stage I to IIIa

Invasion of local structures

Poor prognosis

Ki - 67 labeling index

Distant metastases