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Table 1 The role of cyclin D in several types of cancers

From: Cell cyclins: triggering elements of cancer or not?

Parathyroid adenomas

Cyclin D overexpression in both neoplastic and non- neoplastic proliferating parathyroid tissue.

Papillary thyroid carcinoma

lymph node metastasis

Mantle cell lymphoma

Higher age distribution

Larger cell size

Higher mitotic index

More frequent gastrointestinal involvement

Higher international prognostic index score

Lower p27 expression

Significantly worse survival

breast cancer

higher tumour grade

no correlation with axillary lymph node status or tumour size or HER2 amplification

poorer prognosis

indication for need for additional chemotherapeutic treatment

positive correlation with ER status (p < 0.005)

positive correlation with PR status (p < 0.005)

inverse correlation to Nottingham prognostic index

inverse correlation to membrane EGFR

significantly shorter overall survival and relapse - free survival

tamoxifen resistance