Figure 1
From: P38 MAP Kinase inhibition promotes primary tumour growth via VEGF independent mechanism
The effect of SB-202190 on 4T-1 cells (a) spontaneous apoptosis (Cells 5 × 105 were treated with control (vehicle), 25, 50 or 100 μg/ml of SB-202190 for 24 and 48 hours), (b) proliferation (Cells 2 × 105 were treated with control (vehicle), 25, 50 or 100 μg/ml of SB-202190 for 24 hours, * = p < 0.05), (c) cell cycle analysis (Cells 5 × 105 were treated with control (vehicle), 25, 50 or 100 μg/ml of SB202190 for 24 hours, * = p < 0.05) and (d) Spontaneous VEGF release (Cells 5 × 105 were treated with control (vehicle), 25, 50 or 100 μg/ml of SB-202190 for 6 and 24 hours).