Figure 3

Histopathology of the Pleural Biopsy Hematoxylin and eosin stained, low power magnification ×150. A. Pleural biopsy confirming the presence of black triangle – atypical neoplastic cells infiltrating the fibro connective tissue and adipose tissue of the pleura. The inset in the bottom left shows positive immunohistochemical staining with TTF1 supporting primary lung carcinoma. B. Pleural fluid demonstrates the presence of atypical cells with a high nucleus cytoplasmic ratio supporting a neoplastic lesion. C. Mucosal biopsy of the stomach showing the presence of large atypical malignant cells in the vascular channels with ↑ – enlarged hyperchromatic pleomorphic nuclei consistent with poorly differentiated carcinoma from the lung.