Table 1 Phenotypic markers and chromosomal translocations in common B-cell lymphomas.
S Ig | CD5 | CD10 | CD20 | Other | BCL2 | Cyclin D1 | K aryotype | Oncogene Function | |
|---|---|---|---|---|---|---|---|---|---|
B-CLL/SLL | Weak | + | - | Weak | CD23+ FMC7- | - | Deltion Trisomy | ||
Follicular | ++ | - | + | + | + | + | - | t (14;18) | BCL2 Antiapoptosis |
Mantle cell | ++ | + | - | + | FMC7+ | + | ++ | t (11;14) | Cyclin D1 Cell cycle regulator |
Marginal Zone | + | - | - | + | CD11c+/- | - | No consistant anomaly | ||
Nodal Marginal zone | + | - | - | + | CD11 c+/- | - | t (11;18) | AP12/MALT1 Antiapoptosis | |
MALT large cell | + | - | - | + | +/- | - | t (1;14) t(3;14); t(3;v) | BCL10 Antiapoptosis | |
BCL 6/BCL2 Transcription Factor | |||||||||
Burkitt | + | - | +/- | + | TdT- | - | - | t (8;14) t(2,8) t (8;22) | CMYC Transcription factor |