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Table 3 Association between population characteristics and histological type with 30-bp deletion and Xho I-loss studiesin NPC tissue and plasma samples

From: Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia

  Number of 30-bp deletion in LMP1 (%) Number of Loss of Xho I site (%) Co-existence of 30-bp deletion and Xho I-loss in NPC tissues
  NPC tissues P value NPC plasma P value NPC tissue P value NPC plasma P value Number of co-existence P value
Clinicopathological Features           
Sex           
   Male 14/25 (56.0) 1.000 7/26 (26.9) 1.000 24/27 (88.9) 0.615 9/24 (37.5) 0.529 14/23 (60.9) 0.689
   Female 4/8 (50.0)   0/2 (0.0)¥   9/11 (81.8)   0/2 (0.0)Ω   4/8 (50.0)Ж  
Age           
   <50 years 6/14 (42.9) 0.289 4/15 (26.7) 1.000 12/15 (80.0) 0.630 4/16 (25.0) 0.234 6/13 (46.2) 0.274
   >50 years 11/17 (64.7)§   2/11 (18.2)   19/21 (90.5)   5/10 (50.0)Ω   11/16 (68.8)Φ  
Race           
   Malay 3/15 (20.0) Malay vs. India, p = 1.000 Malay vs. Chinese, p < 0.05* Chinese vs. India, p = 0.158 1/10 (10.0) 0.363 14/19 (73.7) Malay vs. Chinese, p = 0.046* 3/11 (27.3) 0.689 3/14 (21.4) Malay vs. India, p = 1.000
   Chinese 16/18 (88.9)   5/17 (29.4)Ø   19/19 (100.0)   7/17 (41.2)Ψ   16/17 (94.1) Malay vs. Chinese, p < 0.050*
   Indian 0/1 (0.0)     1/1 (100.0)     0/1 (0.0)  
Histological type           
Type I – Keratinizing squamous cell carcinoma (SCC) 1/6 (16.7) SCC vs. NKC, p = 0.600 0/2 (0.0) SCC vs. NKC, p = 1.000 2/5 (40.0) SCC vs. NKC, p = 0.063 0/2 (0.0) SCC vs. NKC, p = 0.429 1/4 (25.0) SCC vs. NKC, p = 1.000
Type II – Non-keratinizing carcinoma (NKC) 5/12 (41.7) SCC vs. UC, p = 0.011* 2/6 (33.3) SCC vs. UC, p = 1.000 14/16 (87.5) SCC vs. UC, p = 0.006* 4/6 (66.7) SCC vs. UC, P = 1.000 5/12 (41.7) SCC vs. UC, p = 0.061
Type III – Undifferentiated carcinoma (UC) 13/16 (81.3) NKC vs. UC, p = 0.050 1/8 (12.5)¤ NKC vs. UC, p = 0.538 18/18 (100.0) NKC vs. UC, p = 0.214 1/10 (10.0)θ NKC vs. UC, p = 0.056 13/16 (81.3) NKC vs. UC, p = 0.050
  1. Statistical significance of the difference was analyzed using Fisher's Exact test, (*) indicates statistical significance (p < 0.05). Data was only available for 33 out of 34 cases.§Data was only available for 31 out of 34 cases. ¥Data was only available for 28 out of 29 cases. Data was only available for 26 out of 29 cases. ØData was only available for 27 out of 29 cases. ¤Data are only available for 16 out of 29 cases. Data was only available for 38 out of 39 cases. The data was only available for 36 out of 39 cases. ΩData was only available for 26 out of 30 cases. ΨData was only available for 28 out of 30 cases. θData was only available for 18 out of 30 cases for NPC plasma samples. ЖData was only available for 31 out of 32 cases for NPC tissues. ΦData was only available for 29 out of 32 cases for NPC tissues.