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Table 3 Association between population characteristics and histological type with 30-bp deletion and Xho I-loss studiesin NPC tissue and plasma samples

From: Epstein-Barr virus latent membrane protein-1 (LMP-1) 30-bp deletion and Xho I-loss is associated with type III nasopharyngeal carcinoma in Malaysia

 

Number of 30-bp deletion in LMP1 (%)

Number of Loss of Xho I site (%)

Co-existence of 30-bp deletion and Xho I-loss in NPC tissues

 

NPC tissues

P value

NPC plasma

P value

NPC tissue

P value

NPC plasma

P value

Number of co-existence

P value

Clinicopathological Features

          

Sex

          

   Male

14/25 (56.0)

1.000

7/26 (26.9)

1.000

24/27 (88.9)

0.615

9/24 (37.5)

0.529

14/23 (60.9)

0.689

   Female

4/8 (50.0)¶

 

0/2 (0.0)Â¥

 

9/11 (81.8)€

 

0/2 (0.0)Ω

 

4/8 (50.0)Ж

 

Age

          

   <50 years

6/14 (42.9)

0.289

4/15 (26.7)

1.000

12/15 (80.0)

0.630

4/16 (25.0)

0.234

6/13 (46.2)

0.274

   >50 years

11/17 (64.7)§

 

2/11 (18.2)∞

 

19/21 (90.5)∂

 

5/10 (50.0)Ω

 

11/16 (68.8)Φ

 

Race

          

   Malay

3/15 (20.0)

Malay vs. India, p = 1.000 Malay vs. Chinese, p < 0.05* Chinese vs. India, p = 0.158

1/10 (10.0)

0.363

14/19 (73.7)

Malay vs. Chinese, p = 0.046*

3/11 (27.3)

0.689

3/14 (21.4)

Malay vs. India, p = 1.000

   Chinese

16/18 (88.9)

 

5/17 (29.4)Ø

 

19/19 (100.0)

 

7/17 (41.2)Ψ

 

16/17 (94.1)

Malay vs. Chinese, p < 0.050*

   Indian

0/1 (0.0)

   

1/1 (100.0)

   

0/1 (0.0)

 

Histological type

          

Type I – Keratinizing squamous cell carcinoma (SCC)

1/6 (16.7)

SCC vs. NKC, p = 0.600

0/2 (0.0)

SCC vs. NKC, p = 1.000

2/5 (40.0)

SCC vs. NKC, p = 0.063

0/2 (0.0)

SCC vs. NKC, p = 0.429

1/4 (25.0)

SCC vs. NKC, p = 1.000

Type II – Non-keratinizing carcinoma (NKC)

5/12 (41.7)

SCC vs. UC, p = 0.011*

2/6 (33.3)

SCC vs. UC, p = 1.000

14/16 (87.5)

SCC vs. UC, p = 0.006*

4/6 (66.7)

SCC vs. UC, P = 1.000

5/12 (41.7)

SCC vs. UC, p = 0.061

Type III – Undifferentiated carcinoma (UC)

13/16 (81.3)

NKC vs. UC, p = 0.050

1/8 (12.5)¤

NKC vs. UC, p = 0.538

18/18 (100.0)

NKC vs. UC, p = 0.214

1/10 (10.0)θ

NKC vs. UC, p = 0.056

13/16 (81.3)

NKC vs. UC, p = 0.050

  1. Statistical significance of the difference was analyzed using Fisher's Exact test, (*) indicates statistical significance (p < 0.05). ¶Data was only available for 33 out of 34 cases.§Data was only available for 31 out of 34 cases. ¥Data was only available for 28 out of 29 cases. ∞Data was only available for 26 out of 29 cases. ØData was only available for 27 out of 29 cases. ¤Data are only available for 16 out of 29 cases. €Data was only available for 38 out of 39 cases. ∂The data was only available for 36 out of 39 cases. ΩData was only available for 26 out of 30 cases. ΨData was only available for 28 out of 30 cases. θData was only available for 18 out of 30 cases for NPC plasma samples. ЖData was only available for 31 out of 32 cases for NPC tissues. ΦData was only available for 29 out of 32 cases for NPC tissues.
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World Journal of Surgical Oncology

ISSN: 1477-7819

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