Figure 4

Case 1: A) Large, simple ducts were surrounded by a uniform, bland stroma in this tumor, which measured 30.0 × 25.0 × 20.0 cm ex vivo. B) The tumor had negative margins of resection that ranged from 0.3 to 1.0 cm. C) The Ki67 proliferation index for the tumor from patient A was 5 for the epithelial component and 13 for the stromal component. Case 2: D) Large, branching ducts were surrounded by a uniform, bland stroma; areas of hyalinization and myxoid change were rare in this 10.0 x 8.0 x 5.0 cm tumor. E) The tumor had negative margins of resection that ranged from 0.3 to 1.0 cm. F) The Ki56 proliferation index for the tumor from patient B was 0.8 for the epithelial component and 4 for the stromal component.