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Table 1 Characteristics of case control studies on Helicobacter sp in benign hepatobiliary diseases and stone diseases.

From: Helicobacter species are associated with possible increase in risk of biliary lithiasis and benign biliary diseases

Reference and year Method of detection Specimen Disease Helicobacter in subjects n/N Helicobacter in controls n/N Organism identified
Myung et al 2000 [3] PCR (UreA) (26 kDa Ag) Intrahepatic Bile, biliary duct tissue, gallbladder Hepatobiliary diseases 4/43 ureA
5/43 26 kDa
0/8
0/23
H. Pylori
Nilsson et al 2000 [4] PCR (16s rRNA) Liver PSC
PBC
9/12
11/12
0/10 control
1/13 NCLC
H. Sp.
Harada et al 2001 [5] PCR (16s rRNA) Bile, biliary epithelium Intrahepatic calculi 3/14 bile
5/8 biliary epithelium
0/9
0/7
Campylobacter sp.
Leong et al 2001 [6] PCR (16s rRNA) Bile CBD stone
Cholangitis
4/25 0/4 H. Sp.
Presser Silva et al 2003 [7] Culture PCR (16s rRNA) Bile
Gallbladder tissue
Cholelithiasis 20/64 culture
28/51 histology
24/56 bile
2/18 H pylori
Chen W et al 2003 [8] PCR Gallbladder Gall stones 29/60 symptomatic
6/10 asymptomatic
15/37 Helicobacter pylori
Vorojova T et al 2006 [9] IgG Elisa Serum Chronic liver disease 13/35
7/32
1/27
4/81; 0/16
7/84; 0/6
12/89; 3/17
H. hepaticus
H. bilis
H. pullorum
Abayli et al 2005 [10] 16s rRNA
PCR
HPE
GB stone Cholesterol stones 7/77 6/20 H pylori
Farshad Sh et al 2004 [11] 16s RNA Stones Bile Gall stones 6/33 stones
4/33 bile
0/40 H pylori
H spp
Bulajic et al 2002 [12] ureA gene PCR Bile Biliary lithiasis cholengitis 26/48 stone
9/17 cholangitis
1/7 H Pylori
Figura et al 1998 [13] CagA Bile gallstones 92/112 90/112 H. pylori
Matsukura et al 2002 [14] PCR 16s rRNA Bile Biliary tract cancer Gallstones 24/29 malignant 18/42 stone 4/14 H bilis
  1. Chr. – chronic; CaGB – gallbladder cancer; CC – cholangiocarcinoma; HCC – hepatocellular carcinoma
  2. PSC – Primary sclerosing cholangitis; PBC – primary biliary cirrhosis; CBD – common bile duct; GB – gallbladder