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Table 5 Studies assessing the prognostic impact of CRM status in oesophageal cancer

From: Emerging aspects of oesophageal and gastro-oesophageal junction cancer histopathology – an update for the surgical oncologist

Author, Date

No.

Country

Type study

Tumour

% CRM involvement

Significance on univariate survival

Significant on multivariate survival

Sagar, 1993 [50]

50

UK

R

Adeno, SCC

40%

Yes (p < 0.05)

Not tested

Saha, 2001 [56]

59

UK

R

Adeno

Unknown

Yes (p < 0.01)

Yes (p < 0.05)

Dexter, 2001 [51]*

135

UK

P

Adeno, SCC

47%

Yes (p < 0.015)

Yes (p = 0.013)

Zafirellis, 2002 [53]*

156

UK

P

Adeno, SCC

42%

Yes (p < 0.0001)

Not significant

Khan, 2003 [54]

329

UK

R

Adeno, SCC

20%

No (p = 0.57)

Not applicable

Roh, 2004 [119]

59

Korea

R

SCC

44%

Yes (p = 0.003)

Not tested

Griffiths, 2006 [52]

249

UK

R

Adeno, SCC

32%

Yes (p = 0.0001)

Yes (p = 0.007)

  1. R = retrospective, P = prospective, Adeno = adenocarcinoma, SCC = squamous cell carcinoma, *These two studies from the same research group include some of the same patients.