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Table 1 Immunohistochemical markers in the differential diagnosis of MCC.

From: Merkel cell carcinoma

 

CK-20

TTF-1

NSE

S-100

GrA

SYP

NFP

CD56

MAP-2

LCA

MCC

+

-

+

-

+/-

+/-

+

+

+

-

SCLC

-

+

+/-

-

-/+

+

-/+

+

+

-

MM

-

-

-

+

-

 

-

 

+

-

LGNEC

+

 

+

 

+

+

-/+

   

Malignant lymphoma

-

-

-

-

-

 

-/+

  

+

  1. + positive, +/- mostly positive, -/+ mostly negative, - negative. CK-20 cytokeratin 20, TTF-1 thyroid transcription factor 1, NSE neuron-spesific enolase, GrA gromogranin A, NFP neurofilament proteins, CD56 neural adhesion molecule, MAP-2 microtubule associated protein 2, LCA leukocyte common antigen SCLC small cell lung carcinoma, MM malignant melanoma, LGNEC low grade neuroendocrine carcinomas