Table 1 Studies assessing efficacy of bilateral prophylactic mastectomy (PM) in BRCA1 and BRCA2 carriers
| Â | Hartmann et al [3] | Meijers-Heijboer et al [4] | Rebbeck et al [5] |
|---|---|---|---|
Study recruitment centers | USA | Netherlands | USA, Canada, UK, Netherlands |
Median follow-up (yrs) | 13.4 | 2.8 | 5.5 |
Mean age at surgery (yrs) | 39 | 36 | 38 |
Number of PM patients | 18 | 76 | 105 |
Number of controls | - | 63 | 378 |
Type of study | Retrospective cohort | Prospective cohort | Case-control |
Primary invasive breast cancer | Â | Â | Â |
- in cases (after PM) | 0 | 0 | 1 (BRCA1 carrier) |
- in controls | - | 8 (13%) | 184 (49%) |