Table 2 Clinical forms of Castleman's disease
From: Surgical management of abdominal and retroperitoneal Castleman's disease
| Â | Localized form | Multifocal form |
|---|---|---|
Mean age (years) | 3rd decade | 6th decade |
Clinical signs | Incidental mass effect | Systemic symptoms |
Localization | Mediastinum, cervical or abdominal, etc... | Multifocal, mostly peripheric lymph nodes |
Histologic type | HV, rarely HV-PC | PC |
Treatment | Surgical resection | Corticosteroids, chimiotherapy, radiotherapy |
Prognosis | Excellent: 100% survival at 5 years | Poor: median survival of 30 months |
Recurrence after treatment | Extremely rare, related to incomplete resection | Nearly always |
Association | Rarely lymphoma | Frequent: AIDS, Kaposi's sarcoma, lymphoma and myeloma |