Skip to main content

Table 4 Chemosensitivity testing in 50 soft tissue sarcoma patients

From: Feasibility of chemosensitivity testing in soft tissue sarcomas

Cytotoxics

Resistant

Low Sensitivity

Moderate Sensitivity

High Sensitivity

Mean Sensitivity Index*

Actinomycin D

00/50 (00%)

10/50 (20%)

03/50 (06%)

37/50 (74%)

137

Doxorubicin (Adriamycin)

03/50 (06%)

02/50 (04%)

10/50 (20%)

35/50 (70%)

140

Ifosfamide

10/50 (32%)

00/50 (00%)

02/50 (04%)

32/50 (64%)

234

Epirubicin

08/50 (16%)

00/50 (00%)

12/50 (24%)

30/50 (60%)

245

Cisplatin

39/50 (82%)

11/50 (22%)

00/50 (00%)

00/50 (00%)

444

Dacarbazine

45/50 (95%)

05/50 (5%)

00/50 (00%)

00/50 (00%)

532

Vincristine

42/50 (84%)

08/50 (16%)

00/50 (00%)

00/50 (00%)

513

Doxorucicin + Ifosfamide

03/50 (06%)

00/50 (00%)

11/50 (22%)

36/50 (72%)

139

Actinomycin D + Ifosfamide

01/50 (2%)

08/50 (16%)

03/50 (06%)

38/50 (76%)

163

VAC**

03/50 (06%)

05/50 (10%)

07/50 (14%)

35/50 (70%)

218

CYVADIC***

02/50 (04%)

00/50 (00%)

15/50 (30%)

33/50 (66%)

255

  1. *Data are means from individual chemosensitivity indices for each test drug or drug combination, which were calculated by summing up the tumor growth inhibition for each drug concentration tested followed by the subtraction of 600. A sensitivity index of 600 indicates unrestrained tumor cell growth and minimal drug sensitivity, whereas a sensitivity index of 0 reflects complete tumor growth inhibition and maximal drug sensitivity.
  2. **VAC: Vincristine, Actinomycin D, Cyclophosphamide
  3. ***CYVADIC: Cyclophosphamide, Vincristine, Doxorubicin, Dacarbazine