Table 1 Cytology of normal hepatocytes and bile duct epithelium.

Arrangement

Singly, 2-dimensional small to large clusters, trabeculae of 2 to 3 cells layer thick

Picket fences with nuclear palisading, monolayered honeycomb sheets

Cells

Polygonal to round

Cuboidal to columnar

Cytoplasm

Abundant dense granular* to vacuolated (lipid/glycogen), pigments (lipofusin, bile, or hemosiderin)

Scant, pale

Nuclei

Round, centrally located, intranuclear cytoplasmic inclusions, nuclear clearing binucleation

Uniform, small, round, more condensed chromatin

Nucleoli

Prominent

Inconspicuous