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Figure 1 | World Journal of Surgical Oncology

Figure 1

From: Barrett's oesophagus and adenocarcinoma

Figure 1

Overview of the G1/S transition of the cell cycle. Following stimulation of proliferation, accumulation of cyclin D1-CDK4/6 complex will lead to phosphorylation of retinoblastoma protein (pRB) thus allowing E2F to promote expression of genes leading to progression from the G1 phase to the S phase of the cell cycle. Cyclin E-CDK2 allow further phosphorylation of RB creating a positive feedback loop. Intracellular or extracellular factors such as DNA damage or lack of required growth factors can influence this process in a negative fashion (e.g.: through p21 or p53).

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