Table 3 Correlation between the clinicopathologic features and HMGB1 expression
Characteristics | HMGB1 | HMGB1 | P value | |
|---|---|---|---|---|
| Â | High expression | Low expression | Â | |
| Â | 52 (69.3%) | 23 (30.7%) | Â | |
Age: mean ± SD (years) |  | 61.6 ± 10.3 | 61.1 ± 10.2 | 0.87 |
Gender | M | 30 (57.7%) | 15 (65.2%) | 0.54 |
| Â | F | 22 (42.3%) | 8 (34.8%) | Â |
Tumor size (mm) ± SE |  | 5.35 ± 1.02 | 2.72 ± 1.53 | 0.16 |
Depth of tumor* | T1 | 5 (9.6%) | 2 (8.7%) | 0.55 |
| Â | T2 | 12 (23.1%) | 9 (39.1%) | Â |
| Â | T3 | 31 (59.6%) | 11 (47.8%) | Â |
| Â | T4 | 4 (7.7%) | 1 (4.4%) | Â |
Lymph node metastasis | Positive | 13 (25.0%) | 2 (8.7%) | 0.08 |
| Â | Negative | 39 (75.0%) | 21 (91.3%) | Â |
Histologic type** | Well | 29 (55.8%) | 20 (87.0%) | 0.02 |
| Â | Moderate | 21 (40.4%) | 3 (13.0%) | Â |
| Â | Mucinous | 2 (3.9%) | 0 (0%) | Â |
Lymphatic invasion | Positive | 7 (13.5%) | 0 (0%) | 0.02 |
| Â | Negative | 45 (86.5%) | 23 (100%) | Â |
Venous invasion | Positive | 31 (59.6%) | 8 (34.8%) | 0.05 |
| Â | Negative | 21 (40.4%) | 15 (65.2%) | Â |
Tumor regression grade | 1 | 36 (69.2%) | 10 (43.5%) | 0.03 |
| Â | 2 | 16 (30.8%) | 13 (56.5%) | Â |
Reduction ratio (%) ± SD |  | 28.9 ± 2.1 | 42.2 ± 3.1 | 0 |
Stage** | 1 | 14 (26.9%) | 9 (39.1%) | 0.22 |
| Â | 2 | 21 (40.4%) | 11 (47.8%) | Â |
| Â | 3 | 11 (21.1%) | 2 (8.7%) | Â |
| Â | 4 | 6 (11.5%) | 1 (4.4%) | Â |