Category | Number of studies (references) | Summary estimate odds ratio (95% CI) | Heterogeneity, I2(%) | pCR rate (95% CI) | |||
---|---|---|---|---|---|---|---|
TNBC (%) | Heterogeneity, I2(%) | non-TNBC (%) | Heterogeneity, I2(%) | ||||
Cycles of NAC | Â | Â | Â | Â | Â | Â | Â |
<4Â cycles | 5.27 (2.57, 10.79) | 0 | 19.6 (13.5, 27.6) | 0 | 4.6 (2.7, 7.8) | 0 | |
4Â cycles | 3.51 (2.21, 5.57) | 0 | 29.2 (23.0, 26.3) | 41.4 | 15.0 (11.8, 18.8) | 35.1 | |
6Â cycles | 3.10 (1.84, 5.22) | 35 | 27.6 (20.3, 36.3) | 0 | 11.0 (8.2, 14.7) | 41.3 | |
>6Â cycles | 2.77 (1.66, 4.61) | 41 | 36.8 (28.8, 45.6) | 33.8 | 17.8 (13.4, 23.3) | 0 | |
Types of NAC regimen | Â | Â | Â | Â | Â | Â | |
Anthracycline-based | 3.19 (2.63, 3.88) | 7 | 26.8 (24.1, 29.6) | 39.8 | 12.1 (10.8, 13.5) | 43.2 | |
Taxane-containing | 3.29 (2.41, 4.48) | 0 | 30.5 (25.9, 35.5) | 38.2 | 14.9 (12.6, 17.5) | 44.8 | |
Platinum-containing | 3.10 (1.59, 6.03) | 0 | 44.2 (30.8, 58.5) | 31.1 | 21.3 (16.3, 27.3) | 43.6 | |
Gemcitabine-containing | 3.49 (1.42, 8.57) | 0 | 44.5 (29.3, 60.8) | 0 | 18.8 (11.2, 29.8) | 30.2 | |
The number of drug in NAC | Â | Â | Â | Â | Â | Â | |
Two kinds of drugs | 3.89 (2.75, 5.49) | 0 | 28.7 (23.8, 34.2) | 36.3 | 12.9 (10.7, 15.5) | 46.1 | |
Three kinds of drugs | 2.39 (1.77, 3.23) | 16 | 22.5 (18.8, 26.5) | 19.8 | 11.2 (9.5, 13.3) | 43.6 | |
Four kinds of drugs | 4.83 (2.80, 8.35) | 0 | 45.7 (35.8, 55.9) | 0 | 15.5 (11.4, 20.6) | 0 | |
Total treatment duration of NAC | Â | Â | Â | Â | Â | Â | |
<12Â weeks | 5.27 (2.57, 10.79) | 0 | 19.6 (13.5, 27.6) | 35.4 | 4.6 (2.7, 7.8) | 0 | |
12Â weeks | 3.42 (2.34, 4.99) | 0 | 24.9 (20.5, 29.9) | 42 | 13.3 (10.7, 16.3) | 42.6 | |
16Â weeks | 2.88 (1.27, 6.56) | 0 | 44.2 (28.4, 61.3) | 41.4 | 24.8 (17.7, 33.7) | 46.7 | |
>16Â weeks | 3.47 (2.80, 4.30) | 7 | 37.6 (34.0, 41.2) | 25.8 | 14.7 (12.9, 16.6) | 38 | |
NAC schedules | Â | Â | Â | Â | Â | Â | Â |
Conventional chemotherapy | 4.40 (3.02, 6.42) | 0 | 24.1 (19.8, 29.0) | 35.6 | 9.7 (7.7, 12.1) | 44.5 | |
Sequential chemotherapy | 2.96 (1.85, 4.72) | 20 | 37.4 (30.0, 45.5) | 22.5 | 17.2 (13.2, 22.1) | 0 |