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Table 2 Genotype frequencies of CDH1 polymorphisms in diffuse gastric cancer cases and controls

From: CDH1 polymorphisms and haplotypes in sporadic diffuse and intestinal gastric cancer: a case–control study based on direct sequencing analysis

Variant

Cases vs. controls

n

(%)

n

(%)

n

(%)

n

(%)

Statistical tests

Fisher’s exact test

χ2test

P-value

Promoter

 

CC

 

CA

 

AA

 

Total

 

10.7858

0.005

0.005

−160C → A

Diffuse

48

44.86%

44

41.12%

15

15.00%

107

100.00%

   
 

Controls

84

62.69%

44

32.84%

6

4.48%

134

100.00%

   

Odds ratioa

 

1

 

1.750 (1.014 to 3.022)

4.375 (1.467 to 14.565)

     

Intron 1

 

TT

 

TC

 

CC

   

1.6397

0.441

0.489

48 + 6 T → C

Diffuse

71

66.36%

32

29.91%

4

3.74%

107

100.00%

   
 

Controls

92

68.66%

33

24.63%

9

6.72%

134

100.00%

   

Odds Ratioa

 

1

 

1.257 (0.677 to 2.328)

0.576 (0.125 to 2.170)

     

Exon 13

 

CC

 

CT

 

TT

   

0.8651

0.649

0.641

2076C → T

Diffuse

45

42.06%

48

44.83%

14

13.08%

107

100.00%

   
 

Controls

55

41.05%

66

49.25%

13

9.70%

134

100.00%

   

Odds ratioa

 

1

 

0.889 (0.499 to 1.584)

1.136 (0.514 to 3.381)

     

Intron 12

 

TT

 

TC

 

CC

   

2.100

0.147

0.182

1937-13 T → C

Diffuse

89

83.18%

18

16.82%

0

0.00%

107

100.00%

   
 

Controls

120

89.55%

14

10.45%

0

0.00%

134

100.00%

   

Odds ratioa

 

1

 

1.734 (0.766 to 3.976)

to

      

Exon 14

 

CC

 

CT

 

TT

   

0.037

0.982

1.000

2253C → T

Diffuse

89

83.18%

17

15.89%

1

0.93%

107

100.00%

   
 

Controls

111

82.84%

22

16.42%

1

0.75%

134

100.00%

   

Odds ratioa

 

1

 

0.964 (0.451 to 1.842)

1.247 (0.016 to 98.766)

     
  1. aAdjusted for age and sex.