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Table 2 Genotype frequencies of CDH1 polymorphisms in diffuse gastric cancer cases and controls

From: CDH1 polymorphisms and haplotypes in sporadic diffuse and intestinal gastric cancer: a case–control study based on direct sequencing analysis

Variant Cases vs. controls n (%) n (%) n (%) n (%) Statistical tests Fisher’s exact test
χ2test P-value
Promoter   CC   CA   AA   Total   10.7858 0.005 0.005
−160C → A Diffuse 48 44.86% 44 41.12% 15 15.00% 107 100.00%    
  Controls 84 62.69% 44 32.84% 6 4.48% 134 100.00%    
Odds ratioa   1   1.750 (1.014 to 3.022) 4.375 (1.467 to 14.565)      
Intron 1   TT   TC   CC     1.6397 0.441 0.489
48 + 6 T → C Diffuse 71 66.36% 32 29.91% 4 3.74% 107 100.00%    
  Controls 92 68.66% 33 24.63% 9 6.72% 134 100.00%    
Odds Ratioa   1   1.257 (0.677 to 2.328) 0.576 (0.125 to 2.170)      
Exon 13   CC   CT   TT     0.8651 0.649 0.641
2076C → T Diffuse 45 42.06% 48 44.83% 14 13.08% 107 100.00%    
  Controls 55 41.05% 66 49.25% 13 9.70% 134 100.00%    
Odds ratioa   1   0.889 (0.499 to 1.584) 1.136 (0.514 to 3.381)      
Intron 12   TT   TC   CC     2.100 0.147 0.182
1937-13 T → C Diffuse 89 83.18% 18 16.82% 0 0.00% 107 100.00%    
  Controls 120 89.55% 14 10.45% 0 0.00% 134 100.00%    
Odds ratioa   1   1.734 (0.766 to 3.976) to       
Exon 14   CC   CT   TT     0.037 0.982 1.000
2253C → T Diffuse 89 83.18% 17 15.89% 1 0.93% 107 100.00%    
  Controls 111 82.84% 22 16.42% 1 0.75% 134 100.00%    
Odds ratioa   1   0.964 (0.451 to 1.842) 1.247 (0.016 to 98.766)      
  1. aAdjusted for age and sex.