|
Variant
|
Cases vs. controls
|
n
|
(%)
|
n
|
(%)
|
n
|
(%)
|
n
|
(%)
|
Statistical tests
|
Fisher’s exact test
|
|---|
|
χ2test
|
P-value
|
|---|
|
Promoter
| |
CC
| |
CA
| |
AA
| |
Total
| |
10.7858
|
0.005
|
0.005
|
|
−160C → A
|
Diffuse
|
48
|
44.86%
|
44
|
41.12%
|
15
|
15.00%
|
107
|
100.00%
| | | |
| |
Controls
|
84
|
62.69%
|
44
|
32.84%
|
6
|
4.48%
|
134
|
100.00%
| | | |
|
Odds ratioa
| |
1
| |
1.750 (1.014 to 3.022)
|
4.375 (1.467 to 14.565)
| | | | | |
|
Intron 1
| |
TT
| |
TC
| |
CC
| | | |
1.6397
|
0.441
|
0.489
|
|
48 + 6 T → C
|
Diffuse
|
71
|
66.36%
|
32
|
29.91%
|
4
|
3.74%
|
107
|
100.00%
| | | |
| |
Controls
|
92
|
68.66%
|
33
|
24.63%
|
9
|
6.72%
|
134
|
100.00%
| | | |
|
Odds Ratioa
| |
1
| |
1.257 (0.677 to 2.328)
|
0.576 (0.125 to 2.170)
| | | | | |
|
Exon 13
| |
CC
| |
CT
| |
TT
| | | |
0.8651
|
0.649
|
0.641
|
|
2076C → T
|
Diffuse
|
45
|
42.06%
|
48
|
44.83%
|
14
|
13.08%
|
107
|
100.00%
| | | |
| |
Controls
|
55
|
41.05%
|
66
|
49.25%
|
13
|
9.70%
|
134
|
100.00%
| | | |
|
Odds ratioa
| |
1
| |
0.889 (0.499 to 1.584)
|
1.136 (0.514 to 3.381)
| | | | | |
|
Intron 12
| |
TT
| |
TC
| |
CC
| | | |
2.100
|
0.147
|
0.182
|
|
1937-13 T → C
|
Diffuse
|
89
|
83.18%
|
18
|
16.82%
|
0
|
0.00%
|
107
|
100.00%
| | | |
| |
Controls
|
120
|
89.55%
|
14
|
10.45%
|
0
|
0.00%
|
134
|
100.00%
| | | |
|
Odds ratioa
| |
1
| |
1.734 (0.766 to 3.976)
|
to
| | | | | | |
|
Exon 14
| |
CC
| |
CT
| |
TT
| | | |
0.037
|
0.982
|
1.000
|
|
2253C → T
|
Diffuse
|
89
|
83.18%
|
17
|
15.89%
|
1
|
0.93%
|
107
|
100.00%
| | | |
| |
Controls
|
111
|
82.84%
|
22
|
16.42%
|
1
|
0.75%
|
134
|
100.00%
| | | |
|
Odds ratioa
| |
1
| |
0.964 (0.451 to 1.842)
|
1.247 (0.016 to 98.766)
| | | | | |
- aAdjusted for age and sex.
