ILC (n = 528) | ||||
---|---|---|---|---|
BCSS HR (95% CI) | P-value | OS HR (95% CI) | P-value | |
Age | ||||
<50 | 1 | 1 | ||
50≤ | 0.898 (0.424 to 1.904) | 0.780 | 0.708 (0.350 to 1.435) | 0.338 |
Surgery | ||||
mastectomy | 1 | 1 | ||
breast conserving surgery | 1.059 (0.520 to 2.157) | 0.874 | 1.224 (0.645 to 2.324) | 0.536 |
Tumor size | ||||
T ≤ 2 cm | 1 | 1 | ||
2 cm < T ≤ 5 cm | 0.524 (0.205 to 1.337) | 0.176 | 0.507 (0.215 to 1.196) | 0.121 |
5 cm < T | 0.275 (0.055 to 1.367) | 0.114 | 0.343 (0.077 to 1.527) | 0.160 |
Nodal status | ||||
0 | 1 | 1 | ||
1 to 3 | 0.156 (0.216 to 1.232) | 0.136 | 0.525 (0.244 to 1.128) | 0.099 |
4 to 9 | 0.307 (0.074 to 1.267) | 0.103 | 0.335 (0.090 to 1.250) | 0.104 |
10≤ | 0.441 (0.103 to 1.886) | 0.270 | 0.449 (0.116 to 1.737) | 0.246 |
TNMstage | ||||
stage I | 1 | 1 | ||
stage II | 1.271 (0.634 to 2.548) | 0.500 | 1.409 (0.753 to 2.639) | 0.284 |
stage III | 4.242 (2.023 to 8.897) | <0.001 | 3.647 (1.826 to 7.285) | <0.001 |
Molecular subtype | ||||
luminal A | 1 | 1 | ||
luminal B | 2.117 (0.903 to 4.961) | 0.084 | 2.157 (0.977 to 4.764) | 0.057 |
HER2-overexpression | 1.499 (0.349 to 6.434) | 0.586 | 1.769 (0.344 to 9.106) | 0.495 |
Triple negative | 3.543 (2.078 to 6.042) | <0.001 | 3.977 (1.653 to 9.565) | 0.002 |
Lymphatic invasion | ||||
no | 1 | 1 | ||
yes | 0.732 (0.389 to 1.375) | 0.332 | 0.802 (0.455 to 1.415) | 0.446 |
Vascular invasion | ||||
no | 1 | 1 | ||
yes | 1.260 (0.690 to 0.299) | 0.452 | 1.068 (0.608 to 1.875) | 0.819 |
Estrogen receptor status | ||||
negative | 1 | 1 | ||
positive | 1.649 (0.464 to 5.859) | 0.439 | 1.657 (0.482 to 5.697) | 0.423 |
Progesterone receptor status | ||||
negative | 1 | 1 | ||
positive | 0.546 (0.277 to 1.076) | 0.080 | 0.568 (0.318 to 1.014) | 0.056 |
HER2 | ||||
negative | 1 | 1 | ||
positive | 3.591 (0.353 to 36.498) | 0.280 | 3.644 (0.395 to 33.657) | 0.254 |
Radiation therapy | ||||
no | 1 | 1 | ||
yes | 0.844 (0.463 to 1.537) | 0.579 | 0.795 (0.456 to 1.387) | 0.419 |
Chemotherapy | ||||
no | 1 | 1 | ||
yes | 1.178 (0.466 to 2.977) | 0.730 | 1.011 (0.453 to 2.259) | 0.979 |
Hormonal therapy | ||||
no | 1 | 1 | ||
yes | 2.063 (0.826 to 5.153) | 0.121 | 2.112 (0.952 to 4.688) | 0.066 |