IDC (n = 14,547) | ||||
---|---|---|---|---|
BCSSHR (95% CI) | P-value | OS HR (95% CI) | P-value | |
Age | ||||
<50 | 1 | 1 | ||
50≤ | 1.060 (0.929 to 1210) | 0.386 | 1.067 (0.944 to 1.206) | 0.302 |
Surgery | ||||
mastectomy | 1 | 1 | ||
breast conserving surgery | 1.049 (0.937 to 1.175) | 0.405 | 1.08 (0.906 to 1.121) | 0.882 |
Tumor size | ||||
T ≤ 2 cm | 1 | 1 | ||
2 cm < T ≤ 5 cm | 1.228 (1.101 to 1.369) | <0.001 | 1.233 (1.112 to 1.366) | <0.001 |
5 cm < T | 1.434 (1.218 to 1.689) | <0.001 | 1.395 (1.192 to 1.632) | <0.001 |
Nodal status | ||||
0 | 1 | 1 | ||
1 to 3 | 1.045 (0.919 to 1.189) | 0.501 | 1.043 (0.926 to 1.174) | 0.488 |
4 to 9 | 0.940 (0.679 to 1.302) | 0.710 | 0.903 (0.662 to 1.233) | 0.522 |
10≤ | 1.018 (0.734 to 1.412) | 0.916 | 0.951 (0.695 to 1.30) | 0752 |
TNMstage | ||||
stage I | 1 | 1 | ||
stage II | 1.090 (0.949 to 1.253) | 0.223 | 1.018 (0.897 to 1.155) | 0.784 |
stage III | 1.563 (1.344 to 1.818) | <0.001 | 1.392 (1.211 to 1.601) | <0.001 |
Molecular subtype | ||||
luminal A | 1 | 1 | ||
luminal B | 1.175 (1.022 to 1.350) | 0.023 | 1.182 (1.039 to 1.344) | 0.011 |
HER2-overexpression | 1.426 (1.200 to 1.695) | <0.001 | 1.406 (1.201 to 1.646) | <0.001 |
Triple negative | 2.523 (2.160 to 2.948) | <0.001 | 2.219 (1.924 to 2.559) | <0.001 |
Lymphatic invasion | ||||
no | 1 | 1 | ||
yes | 4.206 (3.748 to 4.721) | <0.001 | 3.212 (2.899 to 3.559) | <0.001 |
Vascular invasion | ||||
no | 1 | 1 | ||
yes | 3.019 (2.747 to 3.317) | <0.001 | 2.777 (2.540 to 3.036) | <0.001 |
Estrogen receptor status | ||||
negative | 1 | 1 | ||
positive | 0.736 (0.633 to 0.857) | <0.001 | 0.671 (0.585 to 0.771) | <0.001 |
Progesterone receptor status | ||||
negative | 1 | 1 | ||
positive | 0.960 (0.826 to 1.117) | 0.600 | 0.993 (0.861 to 1.146) | 0.928 |
HER2 | ||||
negative | 1 | 1 | ||
positive | 1.426 (1.200 to 1.695) | <0.001 | 1.401 (1.197 to 1.640) | <0.001 |
Radiation therapy | ||||
no | 1 | 1 | ||
yes | 1.012 (0.911 to 1.124) | 0.826 | 1.010 (0.915 to 1.116) | 0.841 |
Chemotherapy | ||||
no | 1 | 1 | ||
yes | 1.059 (0.895 to 1.252) | 0.506 | 1.113 (0.958 to 1.295) | 0.162 |
Hormonal therapy | ||||
no | 1 | 1 | ||
yes | 1.025 (0.914 to 1.149) | 0.671 | 1.007 (0.905 to 1.121) | 0.894 |