Factors that predict lymph node status in clinical stage T1aN0M0 lung adenocarcinomas

Table 1 Prognostic factors and results of univariate analysis for predictors of pathologic nodal involvement in 273 patients with clinical stage T1aN0M0 lung adenocarcinomas

Variable	Total (n = 273)	pN0 (n = 255)	pN1(n = 11)	pN2(n = 7)	P value^a
Age (years)					0.643
≤59	112	103	6	3
>59	161	152	5	4
Gender					0.857
Female	145	136	5	4
Male	128	119	6	3
Smoking history					0.916
Never	164	154	6	4
Current or former	109	101	5	3
Symptoms					0.001
Absent	228	218	5	5
Present	45	37	6	2
Tumor size (cm)					0.854
≤1.0	59	56	2	1
>1.0, ≤2.0	214	199	9	6
GGO status					<0.001
Pure GGO	103	103	0	0
GGO with minimal solid components (<5 mm)	118	118	0	0
Part-solid (solid parts >5 mm)
GGO predominant	5	5	0	0
Solid predominant	8	6	1	1
Pure solid	39	23	10	6
Pleural involvement					0.024
Negative	183	176	5	2
Positive	90	79	6	5
Air bronchogram sign					0.546
Absence	157	147	5	5
Presence	116	108	6	2
CEA (ng/mL)					<0.001
≤5	209	204	3	2
>5	64	51	8	5
Pathologic type					<0.001
Atypical adenomatous hyperplasia (AAH)	20	20	0	0
Adenocarcinoma in situ (AIS)	78	78	0	0
Minimally invasive adenocarcinoma (MIA)	133	133	0	0
Invasive adenocarcinoma	42	24	10	8

^aP value in χ² test or Fisher’s exact tests. CEA, carcinoembryonic antigen; GGO, ground glass opacity.

ISSN: 1477-7819