Table 1 Association of pre-therapy status of tumor markers with clinicopathological parameters
Variable | Cases (N) | CEA (+) N (%) | P value | CA199 (+) N (%) | P value | CA72-4 (+) N (%) | P value | CA125 (+) N (%) | P value | Combined detection (+) N (%) | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|
Gender: | |||||||||||
Male | 127 | 47(39.8) | 32(28.1) | 37(35.6) | 14(23.3) | 78(66.1) | |||||
Female | 57 | 17(33.3) | 0.424 | 15(30.0) | 0.801 | 18(38.3) | 0.748 | 9(33.3) | 0.328 | 30(58.8) | 0.366 |
Age(years): | |||||||||||
≤60 | 92 | 29(33.3) | 25(29.1) | 31(40.8) | 9(22.0) | 52(59.8) | |||||
>60 | 92 | 35(42.7) | 0.210 | 22(28.2) | 0.903 | 24(32.0) | 0.262 | 14(30.4) | 0.370 | 56(68.3) | 0.249 |
Differentiation: | |||||||||||
Moderately | 30 | 18(62.1) | 10(38.5) | 5(20.0) | 4(28.6) | 21(72.4) | |||||
Poorly | 75 | 20(27.4) | 0.001 | 15(20.8) | 0.077 | 24(36.9) | 0.124 | 8(22.2) | 0.918 | 39(53.4) | 0.079 |
Other | 29 | ||||||||||
Missing value: | 50 | ||||||||||
Tumorlocation | |||||||||||
Cardiac carcinoma | 47 | 22(47.8) | 11(24.4) | 11(29.7) | 1(6.2) | 32(69.6) | |||||
Other locations | 114 | 34(31.2) | 0.049 | 28(26.7) | 0.776 | 39(38.6) | 0.336 | 15(24.6) | 0.207 | 64(58.7) | 0.204 |
Missing value | 23 | ||||||||||
Invasion depth(pathological): | |||||||||||
T1 + T2 | 29 | 8(30.8) | 5(20.8) | 5(21.7) | 4(28.6) | 12(46.2) | |||||
T3 + T4 | 146 | 53(39.6) | 0.399 | 39(29.8) | 0.372 | 47(39.5) | 0.106 | 17(25.0) | 1.000 | 90(67.2) | 0.041 |
Missing value | 9 | ||||||||||
Lymph node metastasis (pathological): | |||||||||||
Negative | 44 | 8(20.0) | 7(18.4) | 9(25.7) | 5(26.3) | 19(47.5) | |||||
Positive | 131 | 54(45.0) | 0.005 | 37(31.6) | 0.117 | 42(39.3) | 0.147 | 16(25.4) | 1.000 | 83(69.2) | 0.014 |
Missing value | 9 | ||||||||||
Vascular invasion (pathological) | |||||||||||
Negative | 101 | 32(35.6) | 24(27.6) | 21(26.2) | 14(29.8) | 54(60.0) | |||||
Positive | 66 | 26(41.9) | 0.426 | 19(30.6) | 0.685 | 27(49.1) | 0.006 | 7(21.9) | 0.435 | 43(69.4) | 0.238 |
Missing value | 17 | ||||||||||
pTNM stage: | |||||||||||
I + II | 53 | 13(27.1) | 10(21.3) | 9(20.5) | 7(26.9) | 25(52.1) | |||||
III + IV | 126 | 50(43.1) | 0.055 | 36(32.1) | 0.168 | 45(44.1) | 0.007 | 14(24.1) | 0.785 | 80(69.0) | 0.040 |
Missing value | 5 | ||||||||||
Clinical response: | |||||||||||
PR + SD | 137 | 48(36.9) | 35(27.6) | 40(34.5) | 16(24.6) | 82(63.1) | |||||
PD | 14 | 10(71.4) | 0.012 | 4(28.6) | 1.000 | 4(30.8) | 1.000 | 3(50.0) | 0.389 | 11(78.6) | 0.391 |
Missing value | 33 | ||||||||||
Pathologicresponse: | |||||||||||
Complete and partial response | 84 | 7(24.1) | 6(21.4) | 9(32.1) | 4(25.0) | 14(48.3) | |||||
Noresponse | 33 | 31(39.2) | 0.145 | 21(26.6) | 0.590 | 24(32.9) | 0.944 | 12(26.1) | 1.000 | 52(65.8) | 0.097 |
Missing value | 67 | ||||||||||