Figure 4

ROC curves for the decrease of the four tumor markers to predict the disease control after neoadjuvant chemotherapy. A, B. shows the decrease of CEA, CA199 was not statistically significant (P values were 0.785, and 0.540, respectively). C. The area under the ROC curve of CA72-4 change values was 0.764 (95% CI: 0.584 to 0.945, P = 0.020); the optimal cutoff which simultaneously maximized both the sensitivity (77.8%) and specificity (80%) of the test was decreased by 71.1%. D. The area under the ROC curve of CA125 change values was 0.800 (95% CI: 0.537 to 1.063, P = 0.128); the optimal cutoff which simultaneously maximized both the sensitivity (100%) and specificity (60%) of the test was decreased by 40.0%.