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Table 2 Cox regression of variables associated with tumor recurrence after first hepatectomy for CRCLM

From: Predictors of recurrence after a first hepatectomy for colorectal cancer liver metastases: a retrospective analysis

Variable

Hazard ratio (95% CI)

P

Univariate

  

Sex

1.03 (0.34-3.10)

0.7418

Lobectomy

2.99 (0.93-9.60)

0.0967

Portal embolization or ligature

0.46 (0.15-1.38)

0.1672

Simultaneous resection (liver and primary)

1.37 (0.38-4.93)

0.5338

Anatomical versus non-anatomical resection

2.06 (0.83-9.05)

0.1838

Two-stage hepatectomy

2.32 (0.66-7.05)

0.278

Tumor exposed on the liver surface

4.19 (1.31-13.39)

0.2834

Perioperative systemic therapy

0.82 (0.59-2.64)

0.7510

≥4 liver metastasis

2.97 (1.73-8.25)

0.0831

Macroscopic vascular invasion

3.06 (0.85-11.05)

0.0838

Synchronous liver metastases

4.33 (0.28-9.93)

0.0433a

CEA before hepatectomy ≥50 ng/mL

5.51 (1.47-13.83)

0.0024a

Bilobar disease

5.86 (1.95-17.58)

0.0016a

Surgical margins <5 mm

6.32 (1.90-21.01)

0.0026a

Concomitant resectable intra- and extrahepatic disease

7.03 (2.27-21.80)

0.0007a

Multivariate

  

Concomitant resectable intra- and extrahepatic disease

4.81 (1.61-14.37)

0.0042a

Bilobar disease

4.94 (1.65-14.79)

0.0049a

CEA before hepatectomy ≥50 ng/mL

4.13 (0.41-12.08)

0.0192a

Surgical margins <5 mm

1.82 (0.69-4.64)

0.7510

Synchronous liver metastases

1.23 (0.38-3.93)

0.8831

  1. CEA, carcinoembryonic antigen.
  2. aP < 0.05.