Variable | Hazard ratio (95% CI) | P |
---|---|---|
Univariate | Â | Â |
Sex | 1.03 (0.34-3.10) | 0.7418 |
Lobectomy | 2.99 (0.93-9.60) | 0.0967 |
Portal embolization or ligature | 0.46 (0.15-1.38) | 0.1672 |
Simultaneous resection (liver and primary) | 1.37 (0.38-4.93) | 0.5338 |
Anatomical versus non-anatomical resection | 2.06 (0.83-9.05) | 0.1838 |
Two-stage hepatectomy | 2.32 (0.66-7.05) | 0.278 |
Tumor exposed on the liver surface | 4.19 (1.31-13.39) | 0.2834 |
Perioperative systemic therapy | 0.82 (0.59-2.64) | 0.7510 |
≥4 liver metastasis | 2.97 (1.73-8.25) | 0.0831 |
Macroscopic vascular invasion | 3.06 (0.85-11.05) | 0.0838 |
Synchronous liver metastases | 4.33 (0.28-9.93) | 0.0433a |
CEA before hepatectomy ≥50 ng/mL | 5.51 (1.47-13.83) | 0.0024a |
Bilobar disease | 5.86 (1.95-17.58) | 0.0016a |
Surgical margins <5Â mm | 6.32 (1.90-21.01) | 0.0026a |
Concomitant resectable intra- and extrahepatic disease | 7.03 (2.27-21.80) | 0.0007a |
Multivariate | Â | Â |
Concomitant resectable intra- and extrahepatic disease | 4.81 (1.61-14.37) | 0.0042a |
Bilobar disease | 4.94 (1.65-14.79) | 0.0049a |
CEA before hepatectomy ≥50 ng/mL | 4.13 (0.41-12.08) | 0.0192a |
Surgical margins <5Â mm | 1.82 (0.69-4.64) | 0.7510 |
Synchronous liver metastases | 1.23 (0.38-3.93) | 0.8831 |