DJ-1 is activated in medulloblastoma and is associated with cell proliferation and differentiation

Table 2 Kaplan-Meier analysis for OS rate of patients with MB

Clinicopathological characteristics	Mean survival time, months	95% CI, months	P value^a
Age, year
≤ 3	44.96 ± 5.18	34.81 to 55.12	0.495
>3	47.72 ± 2.72	42.95 to 52.48
Sex
Male	47.16 ± 2.70	41.86 to 52.46	0.880
Female	46.60 ± 4.10	38.56 to 54.64
WHO histological subtype^b
Classic	48.39 ± 2.41	43.66 to 53.12	0.263
Desmoplastic	41.39 ± 5.93	29.76 to 53.02
Tumor location
Fourth ventricle	46.35 ± 3.84	38.82 to 53.88	0.889
Outside fourth ventricle	47.66 ± 2.61	42.44 to 52.87
Residual tumor size
≤1.5 cm²	37.78 ± 6.14	25.73 to 45.83	0.052
>1.5 cm²	49.68 ± 2.28	45.19 to 54.16
Metastatic status
M0	42.08 ± 7.92	26.54 to 57.62	0.971
M1	47.45 ± 2.33	42.87 to 52.02
Tumor risk
Standard	46.64 ± 2.34	41.04 to51.24	0.062
High	23.75 ± 5.20	13.54 to33.95
Differentiation level
Undifferentiated	46.84 ± 3.03	40.89 to 52.79	0.823
Differentiated	46.87 ± 3.52	39.96 to 53.78
DJ-1 expression
Low	53.29 ± 1.79	49.77 to 56.81	0.007
High	40.28 ± 3.79	32.84 to 47.71
p-Akt expression
Low	47.76 ± 3.19	41.50 to 54.03	0.663
High	46.30 ± 3.23	39.97 to 52.63

aLog rank test.
^bWe did not carry out statistical analysis for the large cell/anaplastic variant and medullomyoblastoma because there were insufficient numbers of cases.

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