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Figure 1 | World Journal of Surgical Oncology

Figure 1

From: Neogenin expression is inversely associated with breast cancer grade in ex vivo

Figure 1

Differential expression of neogenin mRNA and protein in breast cancer and in matching distant non-malignant tissues. (A) Immunohistochemistry; a representative case showing strong expression of neogenin protein in the cytoplasm of distant non-cancerous tissue. 200× magnification. (B) Immunohistochemistry; a representative case showing weak expression of neogenin in the cytoplasm of breast cancer tissues (n = 51). 200× magnification. (C) Immunohistochemistry; a representative case showing negative expression of neogenin protein in breast cancer tissue (n = 13). (D) Quantitative real-time PCR; 51 out of 54 cases of breast cancer tissue showed a low level of neogenin mRNA compared to that of the matching distant non-cancerous tissue. The level of neogenin expressed in each distant non-cancerous tissue was normalized to 1 as a control.

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