From: Prognostic value of poorly differentiated clusters in invasive breast cancer
Variable | Univariate | Multivariate | ||||
---|---|---|---|---|---|---|
Hazard ratio | 95% confidence interval | P | Hazard ratio | 95% confidence interval | P | |
Age 40 or younger/>40 | 0.501 | 0.257 to 0.975 | 0.042* | 0.826 | 0.414 to 1.648 | 0.587 |
T stage: T1/T2/T3 | 2.554 | 1.451 to 4.497 | 0.001* | 3.135 | 1.672 to 5.879 | <0.001* |
N stage: N0/N1/N2 or 3 | 2.795 | 1.921 to 4.064 | <0.001* | 2.922 | 1.266 to 6.744 | 0.012* |
Grade: G1/G2/G3 | 1.455 | 0.829 to 2.554 | 0.191 | Not assessed | ||
Lymphovascular invasion: negative/positive | 3.809 | 2.095 to 6.925 | <0.001* | 0.593 | 0.183 to 2.155 | 0.427 |
Estrogen receptor or progesterone receptor: negative/positive | 1.009 | 0.555 to 1.834 | 0.978 | Not assessed | ||
HER-2: negative/positive | 2.064 | 1.031 to 4.133 | 0.041 | 0.820 | 0.383 to 1.758 | 0.610 |
Triple negative status: no/yes | 1.365 | 0.731 to 2.551 | 0.329 | Not assessed | ||
Poorly differentiated cluster grade: G1/ G2/ G3 | 5.086 | 2.998 to 8.628 | <0.001* | 3.811 | 1.992 to 7.289 | <0.001* |
Tumor budding: G1/G2/G3 | 2.554 | 1.721 to 3.792 | <0.001* | 1.808 | 1.159 to 2.820 | 0.009* |