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Table 3 Univariate analysis: clinicopathological features correlated with positive cavity margins

From: HER-2 positive breast cancer is associated with an increased risk of positive cavity margins after initial lumpectomy

Variable

n

OR (95% CI)

P value

BC subtype

   

Luminal B vs. luminal A

154

2.03 (1.34–3.08)

0.001

Luminal-HER-2 vs. luminal A

132

1.43 (0.89–2.28)

0.139

HER-2 vs. luminal A

84

3.45 (2.11–5.63)

<0.001

Triple-negative vs. luminal A

122

0.60 (0.33–1.12)

0.110

Grade

   

G2 vs. G1

590

0.98 (0.56–1.73)

0.947

G3 vs. G1

354

0.99 (0.55–1.79)

0.977

Histological subtype

   

Presence of DCIS vs. IDC

83

2.42 (1.50–3.90)

<0.001

ILC vs. IDC

29

1.83 (0.82–4.09)

0.142

Others vs. IDC

115

0.39 (0.20–0.76)

0.006

Menopausal status

   

Post- vs. pre-

379

0.98 (0.71–1.34)

0.894

cT stage

   

T2/3 vs. T1

398

0.97 (0.71–1.34)

0.873

EIC

102

2.77 (1.80–4.27)

<0.001

LVI

114

1.64 (1.06–2.55)

0.026

Age

   

~50 vs. ≤35

527

1.71 (0.97–3.02)

0.063

>50 vs. ≤35

395

1.35 (0.75–2.44)

0.311

pN stage

   

N1 vs. N0

209

1.56 (1.08–2.25)

0.018

N2 vs. N0

50

1.03 (0.49–2.18)

0.932

N3 vs. N0

30

6.15 (2.92–12.98)

<0.001

pT stage

   

T2 vs. T1

271

1.17 (0.82–1.66)

0.382

  1. Positive CMs include DCIS and invasive carcinoma.
  2. EIC, Extensive intraductal component; LVI, Lymphovascular invasion; ER, Estrogen receptor; PR, Progesterone receptor; HER-2, Human epidermal growth factor receptor 2; DCIS, Ductal carcinoma in situ; IDC, Invasive ductal carcinoma; ILC, Invasive lobular carcinoma; TN, Triple-negative.