High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma

Table 4 Multivariate analysis of factors associated with OS and DFS

Variable	OS			DFS
Variable	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Periostin (Negative versus positive)	3.751	1.564-8.367	0.001	3.403	1.644-7.908	0.001
Pathologic subtype (Conventional versus special)	2.434	1.275-4.564	0.003	2.822	1.577-5.057	0.001
Enneking stage (I, II versus III)	3.156	1.788-5.693	0.000	3.172	1.809-5.629	0.000
Tumor size, cm (≤5 versus >5)	2.039	1.108-3.784	0.021	2.024	1.137-3.70	0.018

CI: Confidence interval; DFS: disease free survival; OS: Overall survival. P <0.05 was considered statistically significant.

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