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Table 5 Relationship between the protein expression of Shh, Gli1, LYVE-1 and VEGF-D and non-small-cell lung cancer a

From: The effects of sonic hedgehog signaling pathway components on non-small-cell lung cancer progression and clinical outcome

Clinicopathological features Shh expression Gli1 expression LYVE-1 expression VEGF-D expression
Negative Positive P Negative Positive P Negative Positive P Negative Positive P
Age, yr             
 <65 11 12 0.117 11 12 0.749 18 5 0.477 14 9 0.11
 ≥65 4 13   9 8   11 6   6 11  
Gender             
 Female 4 6 1.00 5 5 1 6 4 0.418 5 5 1.00
 Male 11 19   15 15   23 7   15 15  
Histology             
 Nonsquamous 8 12 0.744 14 6 0.048 15 5 0.723 10 10 1.00
 Squamous 7 13   6 14   14 6   10 10  
Tumor size             
 <3 cm 11 14 0.273 12 13 0.744 19 6 0.716 13 12 0.744
 ≥3 cm 4 11   8 7   10 5   7 8  
Node stage             
 0 9 18 0.498 12 15 0.311 21 6 0.451 14 13 0.736
 1 to 2 6 7   8 5   8 5   6 7  
VPI             
 No 13 11 0.01 12 12 1.00 17 7 1.00 12 12 1.00
 Yes 2 14   8 8   12 4   8 8  
LTE             
 No 13 22 1.00 17 18 1.00 29 6 0.001 18 17 1.00
 Yes 2 3   3 2   0 5   2 3  
Smoking history             
 No 7 12 0.935 10 9 0.752 13 6 0.583 10 9 0.752
 Yes 8 13   10 11   16 5   10 11  
Tumor recurrence             
 No 11 18 1.00 13 16 0.288 22 7 0.455 14 15 0.723
 Yes 4 7   7 4   7 4   6 5  
Distant metastasis             
 No 14 23 1.00 19 18 1.00 27 10 1.00 19 18 1.00
 Yes 1 2   1 2   2 1   1 2  
  1. aGli1, Glioma-associated oncogene homolog zinc finger protein 1; LTE, Lymphatic thromboembolism; LYVE-1, Lymphatic vessel endothelial hyaluronan receptor 1; Shh, Sonic hedgehog; VEGF-D, Vascular endothelial growth factor D; VPI, Visceral pleura invasion. P-values were calculated using Fisher’s exact test. P < 0.05.