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Table 3 Patient survival or disease progression by total and stratified analyses

From: Prognostic role of microRNA-145 in various human malignant neoplasms: a meta-analysis of 18 related studies

Subgroup

OS

PFSa

n

HR (95% CI)

P value

n

HR (95% CI)

P value

Total

10

0.47 (0.31 to 0.72)b

<0.001

11

0.87 (0.51 to 1.47)b

0.596

Subtotal by ethnicity

      

 White

6

0.67 (0.47 to 0.95)b

0.026

7

1.27 (0.71 to 2.26)b

0.420

 Asian

4

0.35 (0.19 to 0.64)b

0.001

4

0.43 (0.21 to 0.89)b

0.024

Subtotal by disease

      

 Brain glioma

3

0.72 (0.52 to 0.99)b

0.045

–

–

–

 Prostate cancer

–

–

–

3

1.25 (0.45 to 3.48)b

0.671

 Esophageal cancer

–

–

–

2

1.50 (0.53 to 4.22)b

0.443

Subtotal by main pathology

      

 Adeno

3

0.47 (0.14 to 1.61)b

0.228

7

1.01 (0.55 to 1.89)b

0.965

 SCC

2

0.34 (0.13 to 0.93)b

0.035

2

1.50 (0.53 to 4.22)b

0.443

 Glioblastoma

3

0.72 (0.52 to 0.99)b

0.045

–

–

–

  1. OS, overall survival; PFS, progression-free survival including any of relapse-free survival (RFS), disease-free survival (DFS), and metastasis-free survival (MFS); N, number of studies; HR, hazard ratio; CI, confidence interval; SqCa, squamous carcinoma; Adeno, adenocarcinoma.
  2. aPFS included any of the following: DFS, MFS or RFS.
  3. bThe HRs and 95% CIs of the analyzed studies were pooled by the random-effects model if the P value for heterogeneity was less than 0.10 or I2 was greater than 50%.