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Table 2 Patient survival or disease progression associated with miR-145 expression in analyzed studies

From: Prognostic role of microRNA-145 in various human malignant neoplasms: a meta-analysis of 18 related studies

First author, year of publication, and reference Assay method Cut-off value Cases, n OS PFSa
   High expression Low expression HR (95% CI) P HR (95% CI) P
Lee 2013 [5] qRT-PCR Mean NM NM 0.84 (0.74 to 0.97) (M)b 0.017 NM NM
Saija 2013 [6] Microarray Three-fold 215 53 0.67 (0.49 to 0.92) (U)b <0.01 NM NM
Campayo 2013 [7] qRT-PCR Mean 56 14 NM NM 0.30 (0.12 to 0.73) (M)b 0.015
Yu 2013 [11] qRT-PCR Two-fold 125 125 0.21 (0.14 to 0.31) (U)b <0.01 NM NM
Avgeris 2013 [20] qRT-PCR Mean 35 27 NM NM 0.79 (0.31 to 2.04) (M) 0.629
Tang 2013 [21] qRT-PCR Median 77 89 0.28 (0.11 to 0.91) (M) 0.010 0.24 (0.09 to 0.83) (M) 0.008
Tanaka 2013 [22] qRT-PCR Median 32 32 NM NM 0.89 (0.38 to 2.09) (U)b 0.809
Speranza 2012 [23] qRT-PCR Median 8 7 0.23 (0.06 to 0.83) (U)b 0.018 NM NM
Kang 2012 [24] qRT-PCR Median NM NM NM NM 0.68 (0.22 to 2.14) (U) 0.510
Schee 2012 [25] qRT-PCR Median 96 97 NM NM 1.41 (0.76 to 2.59) (U)b 0.290
Law 2012 [9] qRT-PCR 1.5-fold 15 32 NM NM 0.22 (0.09 to 0.57) (U)b <0.05
Ko 2012 [12] qRT-PCR Two-fold 13 12 NM NM 2.56 (1.06 to 6.18) (U)b 0.037
Huang 2012 [26] qRT-PCR Mean 22 22 0.47 (0.17 to 1.33) (M)b 0.072 NM NM
Marchini 2011 [27] qRT-PCR Median NM NM 0.14 (0.03 to 0.75) (M) 0.022 2.24 (0.47 to 10.59) (M) 0.309
Radojicic 2011 [28] qRT-PCR Mean 38 49 1.19 (0.58 to 2.45) (U)b 0.824 1.04 (0.52 to 2.09) (U)b 0.882
Leite 2011 [13] qRT-PCR Mean NM NM NM NM 3.35 (1.32 to 8.50) (M) 0.011
Hamano 2011 [29] qRT-PCR Median 49 49 0.58 (0.33 to 0.99) (U)b 0.023 NM NM
Drebber 2011 [30] qRT-PCR Median 35 15 0.38 (0.11 to 1.31) (U)b 0.244 NM NM
  1. CI, confidence interval; DFS, disease-free survival; HR, hazard ratio; M, multivariate analysis; MFS, metastasis-free survival; NM, not mentioned; OS, overall survival; PFS, progression-free survival; qRT-PCR, quantitative real-time PCR; RFS, relapse-free survival; U, univariate analysis.
  2. aPFS included any of the following: DFS, MFS or RFS.
  3. bHR and 95% CI calculated by survival curve.