Prognostic role of microRNA-145 in various human malignant neoplasms: a meta-analysis of 18 related studies

Table 2 Patient survival or disease progression associated with miR-145 expression in analyzed studies

First author, year of publication, and reference	Assay method	Cut-off value	Cases, n		OS		PFS^a
First author, year of publication, and reference			High expression	Low expression	HR (95% CI)	P	HR (95% CI)	P
Lee 2013 [5]	qRT-PCR	Mean	NM	NM	0.84 (0.74 to 0.97) (M)^b	0.017	NM	NM
Saija 2013 [6]	Microarray	Three-fold	215	53	0.67 (0.49 to 0.92) (U)^b	<0.01	NM	NM
Campayo 2013 [7]	qRT-PCR	Mean	56	14	NM	NM	0.30 (0.12 to 0.73) (M)^b	0.015
Yu 2013 [11]	qRT-PCR	Two-fold	125	125	0.21 (0.14 to 0.31) (U)^b	<0.01	NM	NM
Avgeris 2013 [20]	qRT-PCR	Mean	35	27	NM	NM	0.79 (0.31 to 2.04) (M)	0.629
Tang 2013 [21]	qRT-PCR	Median	77	89	0.28 (0.11 to 0.91) (M)	0.010	0.24 (0.09 to 0.83) (M)	0.008
Tanaka 2013 [22]	qRT-PCR	Median	32	32	NM	NM	0.89 (0.38 to 2.09) (U)^b	0.809
Speranza 2012 [23]	qRT-PCR	Median	8	7	0.23 (0.06 to 0.83) (U)^b	0.018	NM	NM
Kang 2012 [24]	qRT-PCR	Median	NM	NM	NM	NM	0.68 (0.22 to 2.14) (U)	0.510
Schee 2012 [25]	qRT-PCR	Median	96	97	NM	NM	1.41 (0.76 to 2.59) (U)^b	0.290
Law 2012 [9]	qRT-PCR	1.5-fold	15	32	NM	NM	0.22 (0.09 to 0.57) (U)^b	<0.05
Ko 2012 [12]	qRT-PCR	Two-fold	13	12	NM	NM	2.56 (1.06 to 6.18) (U)^b	0.037
Huang 2012 [26]	qRT-PCR	Mean	22	22	0.47 (0.17 to 1.33) (M)^b	0.072	NM	NM
Marchini 2011 [27]	qRT-PCR	Median	NM	NM	0.14 (0.03 to 0.75) (M)	0.022	2.24 (0.47 to 10.59) (M)	0.309
Radojicic 2011 [28]	qRT-PCR	Mean	38	49	1.19 (0.58 to 2.45) (U)^b	0.824	1.04 (0.52 to 2.09) (U)^b	0.882
Leite 2011 [13]	qRT-PCR	Mean	NM	NM	NM	NM	3.35 (1.32 to 8.50) (M)	0.011
Hamano 2011 [29]	qRT-PCR	Median	49	49	0.58 (0.33 to 0.99) (U)^b	0.023	NM	NM
Drebber 2011 [30]	qRT-PCR	Median	35	15	0.38 (0.11 to 1.31) (U)^b	0.244	NM	NM

CI, confidence interval; DFS, disease-free survival; HR, hazard ratio; M, multivariate analysis; MFS, metastasis-free survival; NM, not mentioned; OS, overall survival; PFS, progression-free survival; qRT-PCR, quantitative real-time PCR; RFS, relapse-free survival; U, univariate analysis.
^aPFS included any of the following: DFS, MFS or RFS.
^bHR and 95% CI calculated by survival curve.

ISSN: 1477-7819