Figure 2
From: Breast carcinoma with choriocarcinomatous features: a case report and review of the literature
Histology of breast carcinoma with choriocarcinomatous features (BCCF). (A) Hematoxylin-eosin (HE) staining at a low magnification. The BCCF showed well-demarcated borders with extensive hemorrhage (the BCCF is indicated with black lines), and no infiltrating ductal carcinoma and ductal carcinoma in situ found. Error bars represent 100 μm. (B) Hematoxylin-eosin (HE) staining at a high magnification. A sheet-like arrangement of oval-shaped epithelial cells with prominent nucleoli was seen. Multinucleated giant cells (indicated by black arrows) with oval nuclei, prominent multiple nucleoli, and irregular chromatin clumping resembling syncytiotrophoblastic cells could be also be seen. Error bars represent 50 μm. (C) Immunohistochemistry (IHC) of human chorionic gonadotropin (HCG) demonstrates that all the cancer cells show strong HCG staining. Error bars represent 50 μm.