Table 1 Clinicopathological findings and expression of hypoxic markers
pt | Sex | Age (years) | Patient | Site | Clinical features and smoking history | Duration of presenting symptom | TNM | Treatment | Recurrence | Metastasis | Follow-up | GLUT-1 | HIF-1 | p-Akt | PI3K |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | M | 64 | 1 | right nasal cavity and sinuses | right nasal obstruction and bleeding, no smoking | 2 months | T2N0M0 | right partial maxillectomy and postoperative radiotherapy | yes | No | DOD 22 months | pos | neg | pos | neg |
2 | M | 56 | 2 | left nasal and maxillary sinus | left nasal obstruction and left face numb, 20 cigarettes perday for over 40 years | 1 month | T4N0M0 | CCRT | yes | yes | DOD 22 months | pos | neg | neg | neg |
3 | M | 50 | 3 | supraglottis | odynophagia, hoarseness,40 cigarettes per day for over 15 years | 2 months | T2N0M0 | partial laryngectomy, postoperative CCRT | no | no | alive 26 months | pos | pos | pos | neg |
4 | F | 71 | 4 | subglottis | hoarseness, no smoking | 8 years | T2N0M0 | total laryngectomy | no | no | alive 22 months | pos | pos | neg | pos |
5 | M | 67 | 5 | supraglottis | a progressively enlarging mass in the right side of the neck,20 cigarettes per day for over 20 years | 1 month | T2N2M0 | total laryngectomy and bilateral neck dissection,postoperative CCRT | no | yes | DOD 12 months | pos | neg | neg | pos |
6 | M | 59 | 6 | supraglottis | odynophagia, no smoking | 2 years | T1N0M0 | partial laryngectomy, postoperativeCCRT | yes | yes | DOD 18 months | pos | pos | pos | neg |
7 | M | 58 | 7 | subglottis | progressive hoarseness ,40 cigarettes per day for over 20 years | 3 months | T2N2M0 | total laryngectomy + right neck dissection | no | yes | DOD 6 months | neg | neg | neg | neg |
8 | M | 53 | 8 | supraglottis | hoarseness, 20 cigarettes perday for over 30 years | 2 months | T2N0M0 | partial laryngectomy, postoperative CCRT | no | no | alive 8 months | neg | neg | neg | pos |
9 | M | 66 | 9 | supraglottis | odynophagia, foreign body feeling, 20 cigarettes per day for over 20 years | 2 years | T2N0M0 | partial laryngectomy + bilateral neck dissection, postoperative CCRT | no | no | alive 1 months | pos | pos | pos | neg |
10 | F | 64 | 10 | right nasal and ethmoid sinus | left nasal obstruction, no smoking | 12 months | T2N0M0 | CCRT | yes | yes | DOD 20 months | pos | pos | neg | pos |