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Table 1 Clinicopathological findings and expression of hypoxic markers

From: Clinical features and hypoxic marker expression of primary sinonasal and laryngeal small-cell neuroendocrine carcinoma: a small case series

pt Sex Age (years) Patient Site Clinical features and smoking history Duration of presenting symptom TNM Treatment Recurrence Metastasis Follow-up GLUT-1 HIF-1 p-Akt PI3K
1 M 64 1 right nasal cavity and sinuses right nasal obstruction and bleeding, no smoking 2 months T2N0M0 right partial maxillectomy and postoperative radiotherapy yes No DOD 22 months pos neg pos neg
2 M 56 2 left nasal and maxillary sinus left nasal obstruction and left face numb, 20 cigarettes perday for over 40 years 1 month T4N0M0 CCRT yes yes DOD 22 months pos neg neg neg
3 M 50 3 supraglottis odynophagia, hoarseness,40 cigarettes per day for over 15 years 2 months T2N0M0 partial laryngectomy, postoperative CCRT no no alive 26 months pos pos pos neg
4 F 71 4 subglottis hoarseness, no smoking 8 years T2N0M0 total laryngectomy no no alive 22 months pos pos neg pos
5 M 67 5 supraglottis a progressively enlarging mass in the right side of the neck,20 cigarettes per day for over 20 years 1 month T2N2M0 total laryngectomy and bilateral neck dissection,postoperative CCRT no yes DOD 12 months pos neg neg pos
6 M 59 6 supraglottis odynophagia, no smoking 2 years T1N0M0 partial laryngectomy, postoperativeCCRT yes yes DOD 18 months pos pos pos neg
7 M 58 7 subglottis progressive hoarseness ,40 cigarettes per day for over 20 years 3 months T2N2M0 total laryngectomy + right neck dissection no yes DOD 6 months neg neg neg neg
8 M 53 8 supraglottis hoarseness, 20 cigarettes perday for over 30 years 2 months T2N0M0 partial laryngectomy, postoperative CCRT no no alive 8 months neg neg neg pos
9 M 66 9 supraglottis odynophagia, foreign body feeling, 20 cigarettes per day for over 20 years 2 years T2N0M0 partial laryngectomy + bilateral neck dissection, postoperative CCRT no no alive 1 months pos pos pos neg
10 F 64 10 right nasal and ethmoid sinus left nasal obstruction, no smoking 12 months T2N0M0 CCRT yes yes DOD 20 months pos pos neg pos