Table 1 Clinicopathologic features, treatment, and prognosis of seven cases of primary synovial sarcoma of prostate

Age (years)

37

52

63

44

46

44

22

Clinical findings

Gross hematuria, dysuria, painful micturition

Urinary retention

Lower urinary tract symptoms

Lower urinary tract symptoms

Dysuria, painful micturition

Dysuria gradually

Dysuria, urinary frequency, nocturia, urinary retention

Serum PSA (ng/ml)

None

0.9

0.5

2.91

0.35

1.19

1.2

Extent of tumor

10-cm solid mass with necrosis, invading the prostatic urethra, seminal vesicles, retrovesical soft tissues

7-cm mass, originating in the prostatic fascia of the right lobe

8.5-cm mass extending from the mid-potion of the prostate inferiorly to the base of the penis

6-cm, well circumscribed, soft, heterogeneous mass in the right side of prostate

5.5-cm mass with partial necrosis extending to the pelvic soft tissue

12-cm mass extending to the bladder, the rectum and pelvic soft tissue, partial necrosis

14-cm mass that appeared to originate in the prostatic fascia. Another 8.5-cm mass was found in the right groin area

IHC results

VM+, EMA +

VM+

VM+, CK(CAM5.2)+, S100+, CK7+, CKAE1/3+,CAL+

VM+, CD99+, CK +, bcl-2+

VM+, CD99+, bcl-2+, E-CA+, CK/EMA +

VM+, CK+,CD99+, E-CA+, bcl-2+

VM+, CD99+

Treatment

Chemotherapy, radical prostatocystectomy

Radical prostatectomy, adjuvant chemotherapy

Irradiation with en bloc penectomy and pubectomy and ileal conduit urinary diversion

Radical prostatectomy

Radical prostatectomy, chemotherapy

The tumor could not be completely resected

None

Prognosis

Died (32 months, tumor recurrence and metastasis to the lungs and liver)

Alive (no recurrence or metastasis)

Alive (no recurrence or metastasis)

Alive (no recurrence and metastasis)

Alive (no recurrence and metastasis)

Died (eight months, tumor recurrence and metastasis to the costosternal junction and lung)

Died (three months, multiple lung metastasis and respiratory failure