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Table 3 HR for death in the intention-to-treat population (n = 214)

From: Is concomitant splenectomy beneficial for the long-term survival of patients with gastric cancer undergoing curative gastrectomy? A single-institution study

  Univariate analyses Multivariate analyses
HR (95% CI) P a HR (95% CI) P b
Age, years   0.251   0.242
  ≤ 55 1 (Ref)   1 (Ref)  
  > 55 1.212 (0.872 to 1.685) 0.251 1.427 (0.823 to 2.476) 0.242
Sex   0.444   0.473
 Women 1 (Ref)   1 (Ref)  
 Men 0.867 (0.600 to 1.251) 0.444 0.756 (0.430 to 1.328) 0.473
Tumor size, cm   0.000   0.172
  ≤ 4 1 (Ref)   1 (Ref)  
 5 to 6 1.492 (0.932 to 2.390) 0.096 1.562 (0.763 to 3.199) 0.222
  > 6 2.058 (1.368 to 3.097) 0.001 1.808 (0.928 to 3.522) 0.082
Pathological tumor stage   0.000   0.698
 T1 1 (Ref)   1 (Ref)  
 T2 4.134 (2.968 to 5.756) 0.000 1.484 (0.828 to 2.658) 0.184
 T3 6.508 (4.643 to 9.121) 0.000 1.120 (0.409 to 3.066) 0.826
 T4 9.231 (5.752 to 14.813) 0.000 1.763 (0.149 to 3.906) 0.745
Pathological nodal stage   0.000   0.413
 N0 1 (Ref)   1 (Ref)  
 N1 2.253 (1.912 to 2.654) 0.000 1.201 (0.764 to 1.888) 0.426
 N2 4.128 (3.390 to 5.027) 0.000 1.348 (0.586 to 3.100) 0.482
 N3 8.215 (6.301 to 10.711) 0.000 1.722 (0.515 to 5.756) 0.377
TNM stage   0.000   0.016c
 IA 1 (Ref)   1 (Ref)  
 IB 2.402 (1.611 to 3.580) 0.000 2.778 (1.504 to 5.132) 0.001c
 II 4.589 (3.148 to 6.690) 0.000 5.461 (2.049 to 14.559) 0.001c
 IIIA 8.334 (5.708 to 12.168) 0.000 10.403 (2.567 to 42.162) 0.001c
 IIIB 11.148 (7.406 to 16.782) 0.000 13.570 (2.182 to 84.410) 0.005c
 IV 18.123 (9.654 to 28.184) 0.000 27.360 (3.028 to 47.256) 0.003c
Gross type (Borrmann)   0.001   0.034c
 I 1 (Ref) 0.984 1 (Ref)  
 II 0.989 (0.343 to 2.853)   3.316 (0.727 to 15.120) 0.122
 III 1.337 (0.491 to 3.645) 0.570 3.358 (0.894 to 12.611) 0.073
 IV 2.561 (1.909 to 7.210) 0.025 4.584 (1.201 to 17.499) 0.026c
Type of gastrectomy   0.463   0.297
 Total 1 (Ref)   1 (Ref)  
 Sub-total 0.891 (0.654 to 1.213) 0.463 1.139 (0.722 to 1.796) 0.297
Operation   0.015   0.012c
 Without splenectomy 1 (Ref)   1 (Ref)  
 With splenectomy 1.456 (1.076 to 1.970) 0.015 1.777 (1.137 to 2.777) 0.012c
Complications   0.887   0.173
 No 1 (Ref)   1 (Ref)  
 Yes 0.992 (0.894 to 1.101) 0.887 0.502 (0.254 to 1.193) 0.173
  1. Abbreviations: HR hazard ratio, Ref reference category.
  2. aDerived from tests of HR for prognostic factors in univariate model adjusted for type of surgery in a Cox proportional-hazards model.
  3. bCox-regression analysis, controlling for the prognostic factors listed in the table.
  4. cSignificant.