Is concomitant splenectomy beneficial for the long-term survival of patients with gastric cancer undergoing curative gastrectomy? A single-institution study

Zhang, Hao; Pang, Deyan; Xu, Huanming; Ren, Yuan; Liu, Caigang

doi:10.1186/1477-7819-12-193

Table 3 HR for death in the intention-to-treat population (n = 214)

From: Is concomitant splenectomy beneficial for the long-term survival of patients with gastric cancer undergoing curative gastrectomy? A single-institution study

	Univariate analyses		Multivariate analyses
	HR (95% CI)	P ^a	HR (95% CI)	P ^b
Age, years		0.251		0.242
≤ 55	1 (Ref)		1 (Ref)
> 55	1.212 (0.872 to 1.685)	0.251	1.427 (0.823 to 2.476)	0.242
Sex		0.444		0.473
Women	1 (Ref)		1 (Ref)
Men	0.867 (0.600 to 1.251)	0.444	0.756 (0.430 to 1.328)	0.473
Tumor size, cm		0.000		0.172
≤ 4	1 (Ref)		1 (Ref)
5 to 6	1.492 (0.932 to 2.390)	0.096	1.562 (0.763 to 3.199)	0.222
> 6	2.058 (1.368 to 3.097)	0.001	1.808 (0.928 to 3.522)	0.082
Pathological tumor stage		0.000		0.698
T1	1 (Ref)		1 (Ref)
T2	4.134 (2.968 to 5.756)	0.000	1.484 (0.828 to 2.658)	0.184
T3	6.508 (4.643 to 9.121)	0.000	1.120 (0.409 to 3.066)	0.826
T4	9.231 (5.752 to 14.813)	0.000	1.763 (0.149 to 3.906)	0.745
Pathological nodal stage		0.000		0.413
N0	1 (Ref)		1 (Ref)
N1	2.253 (1.912 to 2.654)	0.000	1.201 (0.764 to 1.888)	0.426
N2	4.128 (3.390 to 5.027)	0.000	1.348 (0.586 to 3.100)	0.482
N3	8.215 (6.301 to 10.711)	0.000	1.722 (0.515 to 5.756)	0.377
TNM stage		0.000		0.016^c
IA	1 (Ref)		1 (Ref)
IB	2.402 (1.611 to 3.580)	0.000	2.778 (1.504 to 5.132)	0.001^c
II	4.589 (3.148 to 6.690)	0.000	5.461 (2.049 to 14.559)	0.001^c
IIIA	8.334 (5.708 to 12.168)	0.000	10.403 (2.567 to 42.162)	0.001^c
IIIB	11.148 (7.406 to 16.782)	0.000	13.570 (2.182 to 84.410)	0.005^c
IV	18.123 (9.654 to 28.184)	0.000	27.360 (3.028 to 47.256)	0.003^c
Gross type (Borrmann)		0.001		0.034^c
I	1 (Ref)	0.984	1 (Ref)
II	0.989 (0.343 to 2.853)		3.316 (0.727 to 15.120)	0.122
III	1.337 (0.491 to 3.645)	0.570	3.358 (0.894 to 12.611)	0.073
IV	2.561 (1.909 to 7.210)	0.025	4.584 (1.201 to 17.499)	0.026^c
Type of gastrectomy		0.463		0.297
Total	1 (Ref)		1 (Ref)
Sub-total	0.891 (0.654 to 1.213)	0.463	1.139 (0.722 to 1.796)	0.297
Operation		0.015		0.012^c
Without splenectomy	1 (Ref)		1 (Ref)
With splenectomy	1.456 (1.076 to 1.970)	0.015	1.777 (1.137 to 2.777)	0.012^c
Complications		0.887		0.173
No	1 (Ref)		1 (Ref)
Yes	0.992 (0.894 to 1.101)	0.887	0.502 (0.254 to 1.193)	0.173

Abbreviations: HR hazard ratio, Ref reference category.
^aDerived from tests of HR for prognostic factors in univariate model adjusted for type of surgery in a Cox proportional-hazards model.
^bCox-regression analysis, controlling for the prognostic factors listed in the table.
^cSignificant.

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ISSN: 1477-7819

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