Table 4 Characteristics of patients with tumors larger than 3 cm
From: Lesson from 610 liver resections of hepatocellular carcinoma in a single center over 10 years
Variables | Group A3 (n = 163) | Group B3 (n = 230) | P-value |
|---|---|---|---|
Age (range) | 51.90 ± 10.14 | 54.59 ± 9.69 | 0.008 |
Gender (male/female) | 131/32 (80.4/19.6%) | 177/53 (77.0/23.0%) | 0.418 |
Etiology | 0.085 | ||
HBV | 125 (76.7%) | 176 (76.5%) | |
HCV | 2 (1.2%) | 12 (5.2%) | |
both | 1 (0.6%) | 3 (1.3%) | |
alcohol | 7 (4.3%) | 3 (1.3%) | |
idiopathic | 28 (17.2%) | 36 (15.7%) | |
Child-Pugh classification | 0.653 | ||
A/B | 160/3 (98.2/1.8%) | 228/2 (99.1/0.9%) | |
Cirrhosis | 66 (40.5%) | 114 (49.6%) | 0.075 |
Serum albumin ≤ 3.5 g/dL | 39 (24.1%) | 25 (10.9%) | < 0.001 |
AST (IU/L) > 50 | 31 (19.1%) | 56 (24.3%) | 0.221 |
ALT (IU/L) > 50 | 38 (23.5%) | 56 (24.3%) | 0.839 |
Operation | 0.004 | ||
minor/major operation | 87/76 (53.4/46.6%) | 89/141 (38.7/61.3%) | |
Perioperative bleeding | 0.131 | ||
≤ 1,000 cc/>1,000 cc | 103/60 (63.2/36.8%) | 162/68 (70.4/29.6%) | |
Perioperative transfusion | 109 (66.9%) | 79 (34.3%) | < 0.001 |
Perioperative complication | 51 (31.3%) | 61 (26.5%) | 0.302 |
Perioperative mortality | 5 (3.1%) | 5 (2.2%) | 0.747 |
Resection margin | 0.002 | ||
≤ 1 cm/>1 cm | 79/72 (52.3/47.7%) | 83/144 (36.6/63.4%) | |
Histologic differentiation | 0.073 | ||
Edmondson-Steiner grade III to IV | 57 (35.0%) | 57 (24.8%) | |
AFP (IU/mL) | 4,129.58 ± 11,213.53 | 3,086.58 ± 10,003.07 | 0.334 |
Multiple tumors | 45 (27.6%) | 38 (16.5%) | 0.008 |
Gross vascular invasion | 10 (6.1%) | 22 (9.6%) | 0.746 |
Microscopic vascular invasion | 103 (63.2%) | 111 (48.3%) | 0.003 |