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Table 4 Characteristics of patients with tumors larger than 3 cm

From: Lesson from 610 liver resections of hepatocellular carcinoma in a single center over 10 years

Variables Group A3 (n = 163) Group B3 (n = 230) P-value
Age (range) 51.90 ± 10.14 54.59 ± 9.69 0.008
Gender (male/female) 131/32 (80.4/19.6%) 177/53 (77.0/23.0%) 0.418
Etiology    0.085
 HBV 125 (76.7%) 176 (76.5%)  
 HCV 2 (1.2%) 12 (5.2%)  
 both 1 (0.6%) 3 (1.3%)  
 alcohol 7 (4.3%) 3 (1.3%)  
 idiopathic 28 (17.2%) 36 (15.7%)  
Child-Pugh classification    0.653
 A/B 160/3 (98.2/1.8%) 228/2 (99.1/0.9%)  
Cirrhosis 66 (40.5%) 114 (49.6%) 0.075
Serum albumin ≤ 3.5 g/dL 39 (24.1%) 25 (10.9%) < 0.001
AST (IU/L) > 50 31 (19.1%) 56 (24.3%) 0.221
ALT (IU/L) > 50 38 (23.5%) 56 (24.3%) 0.839
Operation    0.004
 minor/major operation 87/76 (53.4/46.6%) 89/141 (38.7/61.3%)  
Perioperative bleeding    0.131
 ≤ 1,000 cc/>1,000 cc 103/60 (63.2/36.8%) 162/68 (70.4/29.6%)  
Perioperative transfusion 109 (66.9%) 79 (34.3%) < 0.001
Perioperative complication 51 (31.3%) 61 (26.5%) 0.302
Perioperative mortality 5 (3.1%) 5 (2.2%) 0.747
Resection margin    0.002
 ≤ 1 cm/>1 cm 79/72 (52.3/47.7%) 83/144 (36.6/63.4%)  
Histologic differentiation    0.073
Edmondson-Steiner grade III to IV 57 (35.0%) 57 (24.8%)  
AFP (IU/mL) 4,129.58 ± 11,213.53 3,086.58 ± 10,003.07 0.334
Multiple tumors 45 (27.6%) 38 (16.5%) 0.008
Gross vascular invasion 10 (6.1%) 22 (9.6%) 0.746
Microscopic vascular invasion 103 (63.2%) 111 (48.3%) 0.003
  1. AFP, alpha-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus; HCV, hepatitis C virus.